|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Real time quantitative polymerase chain reaction (qRT-PCR) and Western blot analysis revealed that DAB2 was tumor repressor in PC cells, and its mRNA expression was negatively correlated with miR-93 in PC tissues.
|
30543885 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, we report that the expression of MIR93, noted in two clinically relevant tumor subtypes of GBM, influenced GSC phenotype as well as tumor response to therapy through its effects on autophagy.
|
30654687 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, our study demonstrates that miR-93 may exert an oncogenic function while TIMP2 may act as a tumor suppressor on OS.
|
31383784 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Of note, 16, 14, and 9 miRNAs were significantly increased in PDAC, IPMN, and chronic pancreatitis, respectively, compared with control plasmas. miR-21-5p, miR-33a-3p, miR-320a, and miR-93-5p showed the highest discriminating capacity for pancreatic neoplasia (PDAC or IPMN) with an area under the receiver operating characteristic curve (AUC) of 0.86, 0.85, 0.85, and 0.80, respectively.
|
31009404 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Additionally, in vivo tumorigenic studies on nude mice confirmed that miR-93 mimic treatment accelerated the growth of PC-3 xenograft tumors.
|
30342140 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
L-THP suppressed the expression of miR-93 and increased the levels of PTEN, a crucial tumor suppressor in OC.
|
31128026 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Currently, studies have shown that microRNA-93 (miR-93) can be an oncogene or a tumor suppressor in different kinds of cancers.
|
30390344 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
miR-93 expression was higher in BC tissues than in normal controls, and its expression was associated with tumor stage and node stage.
|
30455080 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The high level of miR-93 was closely associated with larger tumor size (p < 0.05) and poor overall survival (p < 0.05).
|
28592130 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Significantly higher levels were found in high grade tumors for miR-17-5p (p = 0.006), miR-20a-5p (p = 0.007), miR-106b-5p (p = 0.007), miR-93-5p (p = 0.007) and miR-25-3p (p = 0.015) from the paralogous clusters miR-17-92 and miR-106b-25.
|
31581940 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The significant correlation between serum exosomal miR-93 and clinical information including stage, tumor size were observed.
|
29859935 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Dual luciferase reporter assay demonstrated that miR-93-5p directly bound with the 3'-untranslated region of the tumor suppressor gene PTEN and RB1.
|
29309884 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, microRNA-93 (miR-93) and Musashi-1 mediated the tumor suppression of LOCCS knockdown.
|
29110645 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings indicated that miR-93 serves as a tumor promoter in human gastric carcinogenesis by targeting TIMP2, suggesting that miR-93 might be a promising biomarker and therapeutic target for treatment of gastric cancer.
|
29220395 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
PTEN, the tumor-suppressor gene, was discovered to be reduced in breast cancer tissues or MDA-MB-231 cells with high levels of miR-106b and miR-93, which were inversely expressed in PTEN overexpression tissues or cells.
|
28518139 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Dual luciferase reporter assay demonstrated that miR-93 directly bound with the 3'-untranslated region of the tumor suppressor gene <i>LKB1</i>.
|
28382150 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here, we report that two hypoxia-responsive microRNAs, miR-25 and miR-93, are important for establishing an immunosuppressive tumour microenvironment by downregulating expression of the DNA sensor cGAS.
|
28920955 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The level of microRNA-93 (miR-93) in tumors has been recently reported to be negatively correlated with survival of lung cancer patients.
|
26581907 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The mRNA expression levels of the miR-106b-25 cluster (miR-106b, miR-93 and miR-25), and MCM7 in tumor and non-tumor samples were quantitated using quantitative real-time reverse transcription-polymerase chain reaction (q-RT-PCR) analysis, and correlations in the levels of miR-106b, miR-93 and miR-25 expression were calculated.
|
27298561 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, the down-regulation of miR-93 in these cells significantly suppressed tumor growth in vivo.
|
26243299 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A, respectively,and inhibited their expression.
|
25633810 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MiR-93-5P transfection also suppressed tumor development and RhoC expression (determined by immunohistochemistry) in vivo in the xenograft mouse model (p < 0.05).
|
25649143 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings demonstrated that miR-93 promotes tumor growth by directly suppressing CCNG2.
|
25309979 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MiR-93 is thought to be an onco-miRNA for its capabilities of enhancing tumor growth.
|
24606013 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The high expression of miR-20a, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130 was associated with lymph node metastasis (P < 0.05), and high expression of miR-155 was related to tumor penetration through serosa and lymph node metastasis (P < 0.05).
|
22996433 |
2013 |