SMAD2, SMAD family member 2, 4087

N. diseases: 289; N. variants: 8
Disease: Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.070 Biomarker disease BEFREE Identification of novel LncRNA targeting Smad2/PKCα signal pathway to negatively regulate malignant progression of glioblastoma. 31603255 2020
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.070 Biomarker disease BEFREE MiR-145 inhibits EGF-induced epithelial-to-mesenchymal transition via targeting Smad2 in human glioblastoma. 31114250 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.070 Biomarker disease BEFREE In this study, we investigate whether nuclear SMAD2 can restrain the proliferation of glioblastoma. 25832460 2015
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.070 Biomarker disease BEFREE The miRNAs unique to pediatric HGG as compared to adult GBM were predicted to affect PDGFR and SMAD2/3 pathways. 25994230 2015
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.070 AlteredExpression disease BEFREE Here, we report that transforming growth factor-β (TGF-β) is able to induce a mesenchymal phenotype in GBM that involves activation of SMAD2 and ZEB1, a known transcriptional inducer of mesenchymal transition in epithelial cancers. 25275602 2014
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.070 Biomarker disease BEFREE MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma. 21406405 2011
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.070 PosttranslationalModification disease BEFREE Both TGF-beta1- and U87MG-CM-induced Smad-2 phosphorylation and U87MG-CM-induced CLT formation in HBEC were inhibited by the ALK5 antagonist, SB431542. 18711401 2008