SMAD2, SMAD family member 2, 4087

N. diseases: 289; N. variants: 8
Disease: Linear Scleroderma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0263409
Disease: Linear Scleroderma
Linear Scleroderma 		0.010 AlteredExpression disease BEFREE Fibroblasts from LM lesions showed increased migration, proliferation, altered collagen processing, and abnormally high basal levels of phosphorylated SMAD2, thereby rendering them less responsive to transforming growth factor (TGF)-β1 and reducing the degree of myofibroblast differentiation, which is a key component of the wound-healing and scarring process in normal skin. 30367460 2019