SMAD4, SMAD family member 4, 4089

N. diseases: 575; N. variants: 144
Disease: Rectal Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.050 Biomarker disease BEFREE Mutation in BRAF and SMAD4 associated with resistance to neoadjuvant chemoradiation therapy in locally advanced rectal cancer. 31056731 2019
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.050 GeneticVariation disease BEFREE SMAD4 mutation was associated with colon cancer more so than with rectal cancer (odds ratio 2.85; p<0.001), female sex (odds ratio 1.71; p = 0.02), and shorter overall survival than in wild-type SMAD4 cases (median, 29 months versus 56 months; hazard ratio 2.08; p<0.001 [log-rank test]). 28267766 2017
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.050 AlteredExpression disease BEFREE SMAD4 expression was not correlated to prognosis in rectal cancer cases. 21964812 2012
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.050 Biomarker disease BEFREE In this study, we evaluated genetic variation in TGFβ1, TGFβR1, Smad1, Smad2, Smad3, and Smad4 and risk of colon and rectal cancer. 21068203 2011
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.050 Biomarker disease BEFREE Five specific chromosomal aberrations, combined with immunohistochemistry for p53 and SMAD4, can predict possible progression of sessile rectal adenomas to early rectal cancer and can, after validation studies, be added to preoperative staging. 18245538 2008