SMAD4, SMAD family member 4, 4089

N. diseases: 575; N. variants: 144
Disease: Colonic Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.040 AlteredExpression group BEFREE In matched colon tumor cell lines lacking Smad4 or expressing physiological levels of Smad4, an adenoviral version of the vector system attained a significant degree of preferential killing of Smad4-negative tumor cells in response to GCV. 18426856 2008
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.040 AlteredExpression group LHGDN Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells. 17478078 2007
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.040 Biomarker group LHGDN Effect of DPC4 gene on invasion and metastasis of colorectal carcinoma cells. 17151782 2006
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.040 GeneticVariation group BEFREE One of these, DPC4 (deleted in pancreatic cancer 4, also known as SMAD4), is mutated in a minor subset of colorectal carcinomas as well as in germlines of humans predisposed to colon tumours. 12077092 2002