SMAD4, SMAD family member 4, 4089

N. diseases: 575; N. variants: 144
Disease: Malignant transformation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.030 AlteredExpression phenotype BEFREE Malignant transformation was significantly associated with the status of SMAD4 expression (P = 0.0017) and lymphocyte infiltration status (P = 0.0054). 28256094 2017
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.030 AlteredExpression phenotype BEFREE These results directly establish the critical combination of the KRAS oncogene and complete Smad4 inactivation in the multi-stage malignant transformation and metastatic progression of normal human HPDE cells. 24386371 2013
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.030 Biomarker phenotype BEFREE These findings indicated that Deleted in pancreatic carcinoma locus 4 might be an important biomarker for malignant transformation and be involved in inducing apoptosis by modulating Bcl-2/Bax balance. 18620728 2008