MAG, myelin associated glycoprotein, 4099

N. diseases: 106; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4225250
Disease: SPASTIC PARAPLEGIA 75, AUTOSOMAL RECESSIVE
SPASTIC PARAPLEGIA 75, AUTOSOMAL RECESSIVE 		0.700 GeneticVariation disease UNIPROT Neurologic syndrome associated with homozygous mutation at MAG sialic acid binding site. 27606346 2016
CUI: C4225250
Disease: SPASTIC PARAPLEGIA 75, AUTOSOMAL RECESSIVE
SPASTIC PARAPLEGIA 75, AUTOSOMAL RECESSIVE 		0.700 GermlineCausalMutation disease ORPHANET Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder. 26179919 2015
CUI: C4225250
Disease: SPASTIC PARAPLEGIA 75, AUTOSOMAL RECESSIVE
SPASTIC PARAPLEGIA 75, AUTOSOMAL RECESSIVE 		0.700 Biomarker disease GENOMICS_ENGLAND Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder. 26179919 2015
CUI: C4225250
Disease: SPASTIC PARAPLEGIA 75, AUTOSOMAL RECESSIVE
SPASTIC PARAPLEGIA 75, AUTOSOMAL RECESSIVE 		0.700 GeneticVariation disease UNIPROT Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder. 26179919 2015
CUI: C4225250
Disease: SPASTIC PARAPLEGIA 75, AUTOSOMAL RECESSIVE
SPASTIC PARAPLEGIA 75, AUTOSOMAL RECESSIVE 		0.700 Biomarker disease GENOMICS_ENGLAND Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder. 26179919 2015
CUI: C4225250
Disease: SPASTIC PARAPLEGIA 75, AUTOSOMAL RECESSIVE
SPASTIC PARAPLEGIA 75, AUTOSOMAL RECESSIVE 		0.700 GeneticVariation disease UNIPROT Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. 24482476 2014
CUI: C4225250
Disease: SPASTIC PARAPLEGIA 75, AUTOSOMAL RECESSIVE
SPASTIC PARAPLEGIA 75, AUTOSOMAL RECESSIVE 		0.700 Biomarker disease GENOMICS_ENGLAND Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. 24482476 2014
CUI: C4225250
Disease: SPASTIC PARAPLEGIA 75, AUTOSOMAL RECESSIVE
SPASTIC PARAPLEGIA 75, AUTOSOMAL RECESSIVE 		0.700 CausalMutation disease CLINVAR
CUI: C4225250
Disease: SPASTIC PARAPLEGIA 75, AUTOSOMAL RECESSIVE
SPASTIC PARAPLEGIA 75, AUTOSOMAL RECESSIVE 		0.700 Biomarker disease CTD_human
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 GeneticVariation disease BEFREE Allelic tests showed nominally significant association of two RTN4 SNPs (P = 0.047 and 0.037 for rs11894868 and rs2968804, respectively) and two MAG SNPs (P = 0.034 and 0.029 for rs7249617 and rs16970218, respectively) with schizophrenia. 21563301 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease PSYGENET Allelic tests showed nominally significant association of two RTN4 SNPs (P = 0.047 and 0.037 for rs11894868 and rs2968804, respectively) and two MAG SNPs (P = 0.034 and 0.029 for rs7249617 and rs16970218, respectively) with schizophrenia. 21563301 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease PSYGENET Our finding provides support for potential association of the CNP gene but not the MAG gene in schizophrenia in a Caucasian population. 18496213 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease BEFREE We assessed the mRNA expression levels of four oligodendrocyte-related genes: myelin-associated basic protein (MOBP), myelin-associated glycoprotein (MAG), 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) and oligodendrocyte-lineage transcription factor 2 (OLIG2) in DLPFC white and grey matter using quantitative-PCR (approximately 70 controls and approximately 30 patients with schizophrenia). 17964117 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 AlteredExpression disease LHGDN Expression of MAG, CNP and OLIG2 did not differ between patients with schizophrenia and controls in the grey or white matter but MOBP mRNA levels were increased in the DLPFC white matter in patients with a history of substance abuse. 17964117 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease BEFREE Our finding provides support for potential association of the CNP gene but not the MAG gene in schizophrenia in a Caucasian population. 18496213 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease PSYGENET Expression of MAG, CNP and OLIG2 did not differ between patients with schizophrenia and controls in the grey or white matter but MOBP mRNA levels were increased in the DLPFC white matter in patients with a history of substance abuse. 17964117 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease BEFREE Using in situ hybridization, we measured transcript expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), myelin-associated glycoprotein (MAG), transferrin (TF), quaking (QKI), gelsolin, myelin oligodendrocyte glycoprotein, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3, erbb2 interacting protein, motility-related protein-1, SRY-box containing gene 10, oligodendrocyte transcription factor 2, peripheral myelin protein 22, and claudin-11 in both gray and white matter of the anterior cingulate cortex (ACC) in subjects with schizophrenia (n=41) and a comparison group (n=34). 17223013 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease BEFREE The MAG knockout mouse, missing a myelin-related gene linked to schizophrenia, may prove to be a useful animal model for the dysmyelination observed in the human disease. 17291369 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 AlteredExpression disease BEFREE Changes in oligodendroglia-related genes reported in SZ, BD and MDD appear to display considerable similarities (particularly decreased expression of MAG, ERBB, TF, PLP1, MOG, MOBP, MOG), while changes in cocaine abuse and alcoholism are more diverse. 17291372 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease PSYGENET Using in situ hybridization, we measured transcript expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), myelin-associated glycoprotein (MAG), transferrin (TF), quaking (QKI), gelsolin, myelin oligodendrocyte glycoprotein, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3, erbb2 interacting protein, motility-related protein-1, SRY-box containing gene 10, oligodendrocyte transcription factor 2, peripheral myelin protein 22, and claudin-11 in both gray and white matter of the anterior cingulate cortex (ACC) in subjects with schizophrenia (n=41) and a comparison group (n=34). 17223013 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 AlteredExpression disease BEFREE In addition, the tightly coexpressed myelin-related genes (PLP1, MAG, and TF) have decreased mRNA levels in 55 schizophrenic patients, as compared with 55 control individuals, and most of this difference (68-96%) can be explained by variation in the relative mRNA levels of QKI-7kb, the same QKI splice variant previously shown to be down-regulated in patients with schizophrenia. 16641098 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 AlteredExpression disease BEFREE Correlation and factor analyses revealed that mRNA levels for genes that did exhibit differential expression in schizophrenia (MAG, CNP, SOX10, CLDN11, and PMP2), as opposed to those that did not (MOBP and MBP), loaded on separate factors. 16213148 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease PSYGENET Our findings of a significant associations between schizophrenia and the MAG gene suggest that this gene may be involved in susceptibility to schizophrenia in the Chinese Han population. 16039057 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease BEFREE Our findings of a significant associations between schizophrenia and the MAG gene suggest that this gene may be involved in susceptibility to schizophrenia in the Chinese Han population. 16039057 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease LHGDN The results demonstrated MAG might play a role in genetic susceptibility to schizophrenia. 15820319 2005