Memory impairment
|
0.500 |
Biomarker
|
phenotype |
HPO |
|
|
|
Memory impairment
|
0.500 |
CausalMutation
|
phenotype |
CLINVAR |
|
|
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
CTD_human |
Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau.
|
12368474 |
2002 |
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
Alzheimer's disease (AD) is defined by senile plaques made of amyloid-beta peptide (Abeta), neurofibrillary tangles made of hyperphosphorylated tau proteins, and memory deficits.
|
20463407 |
2010 |
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
At clinical presentation, familial FTLD-TDP patients were older at onset (p = 0.030) and had more memory deficits (p = 0.011), whereas patients with MAPT had more naming deficits (p < 0.001) and obsessive-compulsive behavior (p = 0.001).
|
21753175 |
2011 |
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
SuHeXiang Wan essential oil alleviates amyloid beta induced memory impairment through inhibition of tau protein phosphorylation in mice.
|
21905282 |
2011 |
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
CTD_human |
A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease.
|
22430071 |
2012 |
Memory impairment
|
0.500 |
GeneticVariation
|
phenotype |
BEFREE |
We show for the first time that hippocampal GABAergic function is impaired by pathological tau protein, leading to altered synaptic plasticity and severe memory deficits.
|
24252661 |
2013 |
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
CTD_human |
Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity.
|
24556215 |
2014 |
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
The associations between the loops and behaviours further suggest that tau protein pathway genes do play a significant role in non-episodic memory impairment.
|
25344117 |
2016 |
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
However, the exact mechanism through which arctigenin improves amyloid beta-induced memory impairment by inhibiting the production of the hyperphosphorylated tau protein is unknown.
|
27224270 |
2017 |
Memory impairment
|
0.500 |
GeneticVariation
|
phenotype |
BEFREE |
Uncleavable SRPK2 N342A expression improves synaptic functions and prevents spatial memory deficits in tau intronic mutant FTDP-17 transgenic mice.
|
30373880 |
2018 |
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
CTD_human |
Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy.
|
29860433 |
2018 |
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
Study of molecular mechanisms of learning and memory impairment in neonatal rats post intrauterine distress via the pathway of Tau protein hyperphosphorylation.
|
29771431 |
2018 |
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
CTD_human |
Importance of tau in cognitive decline as revealed by developmental exposure to lead.
|
29203278 |
2018 |
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
Mice receiving endothelium-derived amyloid and tau proteins <i>via</i> intracerebroventricular injection exhibit a learning and memory deficit in object recognition, fear conditioning, and Morris water maze studies.
|
31211919 |
2019 |
Memory impairment
|
0.500 |
AlteredExpression
|
phenotype |
BEFREE |
The data observed show that neonatal immune activation may be associated with visuospatial memory impairment, neuroinflammation, and increased expression of GSK-3<i>β</i> and Tau proteins in the long term.
|
31467920 |
2019 |