MAT1A, methionine adenosyltransferase 1A, 4143

N. diseases: 103; N. variants: 15
Disease: Liver neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.040 AlteredExpression group BEFREE Expression of MAFG and MAT2A increased, and expression of MAT1A decreased, in diethylnitrosamine-induced liver tumors in mice. 29733835 2018
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.040 AlteredExpression group BEFREE 5-Aza-2<-deoxycytidine induces hepatoma cell apoptosis via enhancing methionine adenosyltransferase 1A expression and inducing S-adenosylmethionine production. 24377546 2013
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.040 Biomarker group BEFREE Since SAM is a driver of hepatocytes fate we have studied the effect of re-expressing MAT1A in hepatoma Huh7 cells using proteomics. 22270009 2012
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.040 Biomarker group BEFREE In this study, we isolated a cell line (SAMe-deficient [SAMe-D]) from MAT1A knockout (MAT1A-KO) mouse HCC to examine the role of LKB1 in the development of liver tumors derived from metabolic disorders. 20815019 2010