MAT2A, methionine adenosyltransferase 2A, 4144

N. diseases: 81; N. variants: 1
Disease: Hepatocarcinogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis 		0.020 Biomarker disease BEFREE Therefore, MAT1A:MAT2A switch contributes to decrease in SAM level in rodent and human hepatocarcinogenesis. 23665184 2013
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis 		0.020 GeneticVariation disease BEFREE Here we found Mat1A:Mat2A switch and low SAM levels, associated with CpG hypermethylation and histone H4 deacetylation of Mat1A promoter, and prevalent CpG hypomethylation and histone H4 acetylation in Mat2A promoter of fast-growing HCC of F344 rats, genetically susceptible to hepatocarcinogenesis. 22318685 2012