MC4R, melanocortin 4 receptor, 4160

N. diseases: 149; N. variants: 58
Disease: Multiple Sclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.020 AlteredExpression disease BEFREE We identified MC4R mRNA and protein to be expressed on astrocytes and observed increased astrocytic MC4R expression in active MS lesions. 31636637 2019
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.020 AlteredExpression disease BEFREE We reported that oligodendroglia (OL) and oligodendroglial precursor cells (OPC) express MC4R, and that ACTH 1-39 protects OL and OPC in vitro from cell death induced by mechanisms likely involved in white matter damage in MS. 28877366 2018