|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, the cell-surface adhesion molecule MCAM/MUC18 that is involved in metastasis of human melanoma was downregulated in the KCREB-transfected cells.
|
9366524 |
1997 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains.
|
8378324 |
1993 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sequential molecular analysis of circulating MCAM/MUC18 expression: a promising disease biomarker related to clinical outcome in melanoma.
|
24902661 |
2014 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Protein levels of MCAM correlate with aggressive invasive behavior of melanoma cells in vitro and invivo.
|
15610525 |
2004 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD146 predicted poor prognosis of a variety of cancers including melanoma, breast tumors, prostate cancer, and gastric cancer.
|
26928402 |
2016 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further analysis of MCAM(KD) or ST6(O/E) melanoma cells in cell migration assays indicated that Gal-1 ligand-dependent melanoma cell migration was severely inhibited.
|
25756799 |
2015 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ectopic expression of MCAM into primary cutaneous melanoma cells enhanced their tumorigenicity and metastatic ability in vivo.
|
9810513 |
1998 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our results demonstrate that the elevated MCAM expression due to miR-573 reduction is essential in melanoma initiation and progression.
|
23670160 |
2013 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Given that monoclonal antibodies against MUC18 are in preclinical development but the reason for their antitumor activity is not well understood, these translational results are relevant in the setting of human melanoma and perhaps of other cancers.
|
18922915 |
2008 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Melanoma cell adhesion molecule is a novel marker for human fetal myogenic cells and affects myoblast fusion.
|
16835268 |
2006 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cell surface glycoprotein MUC18 (alias CD146 or melanoma cell adhesion molecule) has been shown to promote metastasis in several tumors, including melanoma.
|
23256918 |
2013 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data link AKT activation with MelCAM expression, and implicate that intervention of MelCAM-AKT signaling axis in melanoma is a potential therapeutical approach.
|
14534536 |
2003 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Direct correlation between MUC18 expression and metastatic potential of human melanoma cells.
|
8471835 |
1993 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this report, we extended investigation of effects of moMCAM/MUC18 expression on tumorigenesis and metastasis in another lowly metastatic, however highly tumorigenic moMCAM/MUC18-minus mouse melanoma K1735 subline, K9 (tumor<sup>+++</sup>/met<sup>low</sup>).
|
27510563 |
2016 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Loss of AP-2α and overexpression of CREB/ATF-1 results in the overexpression of MCAM/MUC18 which by itself contributes to melanoma metastasis by regulating the inhibitor of DNA binding-1 (Id-1).
|
21147226 |
2011 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
All melanoma-associated gene markers were expressed in at least 80% of the melanoma lines, whereas 37 of 39 normal PBL tested negative for all markers; the remaining two PBL were positive for MUC18.
|
7636555 |
1995 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The mechanisms for upregulation of the melanoma cell adhesion molecule during melanoma progression are, however, still poorly understood.
|
10571724 |
1999 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In an effort to validate the use of tissue microarray for melanoma immunohistochemical investigation, a study was conducted comparing the concordance of MCAM staining between whole tumour specimens and tissue microarray core biopsies.
|
15091192 |
2004 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD146 is an adhesion molecule present on many tumors (melanoma, kidney, pancreas, breast, ...).
|
29348825 |
2017 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Besides in melanoma, expression of CD146 antigen has been demonstrated in breast epithelia and hair follicles.
|
10951239 |
2000 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that MCAM expression by melanoma cells is associated with increased homotypic adhesion, an event that may support tumor cell survival and growth in vivo.
|
9398060 |
1997 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
The characterization of the invasion phenotype of uveal melanoma tumour cells shows the presence of MUC18 and HMG-1 metastasis markers and leads to the identification of DJ-1 as a potential serum biomarker.
|
16570276 |
2006 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CD146 expression can promote tumour progression in human melanoma, possibly through enhanced interaction between melanoma cells and endothelial cells.
|
10451481 |
1999 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate the immunohistochemical expression of MCAM/CD146 in 51 canine melanomas, including oral, cutaneous and ocular tumours.
|
28735667 |
2017 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Melanoma-associated markers expression in blood: MUC-18 is associated with advanced stages in melanoma patients.
|
19067715 |
2009 |