|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
<sup>89</sup>Zr-Df-YY146 PET readily detects CD146-positive A375 melanomas.
|
31065511 |
2019 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
S100A8/A9-MCAM binding activates mitogen-activated protein kinase kinase kinase 8 (MAP3K8), also termed TPL2, leading to strong activation of the transcription factor ETV4 and subsequent induction of matrix metalloproteinase-25 (MMP25), and finally to induction of melanoma lung tropic metastasis.
|
30904617 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The CD146 (also known as MCAM, MUC-18, Mel-CAM) was initially reported in 1987, as a protein crucial for the invasiveness of malignant melanoma.
|
31826047 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Wnt5a signaling results in acyl protein thioesterase 1 (APT1) mediated depalmitoylation of pro-metastatic cell adhesion molecules CD44 and MCAM, resulting in increased melanoma invasion.
|
29648538 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, our results showed that GCNT3 is an upstream regulator of MCAM protein and indicate the possibility of a potential molecular target in melanoma therapeutics through abrogation of the S100A8/A9-MCAM axis.
|
28923134 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD146 is an adhesion molecule present on many tumors (melanoma, kidney, pancreas, breast, ...).
|
29348825 |
2017 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate the immunohistochemical expression of MCAM/CD146 in 51 canine melanomas, including oral, cutaneous and ocular tumours.
|
28735667 |
2017 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-κB and ROS formation upon ligand binding.
|
27151304 |
2016 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD146 predicted poor prognosis of a variety of cancers including melanoma, breast tumors, prostate cancer, and gastric cancer.
|
26928402 |
2016 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this report, we extended investigation of effects of moMCAM/MUC18 expression on tumorigenesis and metastasis in another lowly metastatic, however highly tumorigenic moMCAM/MUC18-minus mouse melanoma K1735 subline, K9 (tumor<sup>+++</sup>/met<sup>low</sup>).
|
27510563 |
2016 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
As MUC18 has proangiogenic potency in melanoma and prostate cancer this study investigated the role of MUC18 in patients with stenotic or dilatative arteriosclerotic disease as a putative biochemical marker.
|
25729916 |
2015 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further analysis of MCAM(KD) or ST6(O/E) melanoma cells in cell migration assays indicated that Gal-1 ligand-dependent melanoma cell migration was severely inhibited.
|
25756799 |
2015 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sequential molecular analysis of circulating MCAM/MUC18 expression: a promising disease biomarker related to clinical outcome in melanoma.
|
24902661 |
2014 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Various approaches for targeting CD146 in melanoma cells have been exploited and CD146 has been shown to be a promising target for antitumor therapy.
|
23370332 |
2013 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our results demonstrate that the elevated MCAM expression due to miR-573 reduction is essential in melanoma initiation and progression.
|
23670160 |
2013 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cell surface glycoprotein MUC18 (alias CD146 or melanoma cell adhesion molecule) has been shown to promote metastasis in several tumors, including melanoma.
|
23256918 |
2013 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To our knowledge, this is the first demonstration that MUC18 is involved in cell signaling regulating the expression of Id-1 and ATF-3, thus contributing to melanoma metastasis.
|
21467165 |
2011 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of melanoma-associated genes (N-cadherin, MUC-18, integrin β3, α3, α5, αv, SLUG, TBX3, HIF1-α, BMP-4 and bFGF) was enhanced in MBrc which were de-differentiated out of melanocytes.
|
21496114 |
2011 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Of the genes identified, seven genes: galectin 3 (Lgals3), melanoma cell adhesion molecule (Mcam), fibronectin 1 (Fn1), signal transducer and activator of transcription 3 (Stat3), microphthalmia-associated transcription factor (Mitf), max interacting protein 1 (Max1), and non-metastatic cells 1, protein (NM23A) expressed in (Nme1) are known to be associated with melanoma, but have not yet been reported as being regulated by hypoxia in human melanoma cells.
|
21912348 |
2011 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Loss of AP-2α and overexpression of CREB/ATF-1 results in the overexpression of MCAM/MUC18 which by itself contributes to melanoma metastasis by regulating the inhibitor of DNA binding-1 (Id-1).
|
21147226 |
2011 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD146 (MCAM) is associated with an advanced tumor stage in melanoma, prostate cancer and ovarian cancer.
|
19123925 |
2009 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Co-immunoprecipitation and bioluminescence resonance energy transfer (BRET) experiments indicate that hShrm1 and MCAM interact in vivo and by immunofluorescence microscopy some co-localization of these proteins is observed. hShrm1 partly co-localises with beta-actin and is found in the Triton X-100 insoluble fraction of melanoma cell extracts.
|
19137261 |
2009 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Melanoma-associated markers expression in blood: MUC-18 is associated with advanced stages in melanoma patients.
|
19067715 |
2009 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Given that monoclonal antibodies against MUC18 are in preclinical development but the reason for their antitumor activity is not well understood, these translational results are relevant in the setting of human melanoma and perhaps of other cancers.
|
18922915 |
2008 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
These observations further suggest a role for MUC18 in uveal melanoma growth; moreover, interactions between MUC18-positive melanoma cells and vasculature may be important for the hematogenous spread of cells during metastases.
|
17786470 |
2007 |