MDM2, MDM2 proto-oncogene, 4193

N. diseases: 702; N. variants: 30
Disease: Prostatic Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.330 AlteredExpression group BEFREE We demonstrated that human prostate tumors had increased expression of MDM2 and mutant p53 proteins. 21444629 2011
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.330 Biomarker group CTD_human Association between polymorphisms of TP53 and MDM2 and prostate cancer risk in southern Chinese. 20875869 2010
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.330 GeneticVariation group LHGDN Mdm2-SNP309 polymorphism in prostate cancer: no evidence for association with increased risk or histopathological tumour characteristics. 18577987 2008
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.330 Biomarker group BEFREE These results indicate that MDM2 has a role in prostate tumor growth through both p53-dependent and p53-independent mechanisms, indicating that MDM2 inhibitors have a broad spectrum of anti-tumor activities in human prostate cancers regardless of p53 status. 12518324 2003