MDM2, MDM2 proto-oncogene, 4193

N. diseases: 702; N. variants: 30
Disease: Cutaneous Melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.080 Biomarker disease BEFREE ATM Dependent DUSP6 Modulation of p53 Involved in Synergistic Targeting of MAPK and p53 Pathways with Trametinib and MDM2 Inhibitors in Cutaneous Melanoma. 30577494 2018
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.080 AlteredExpression disease BEFREE Targeting negative regulation of p53 by MDM2 and WIP1 as a therapeutic strategy in cutaneous melanoma. 29235570 2018
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.080 Biomarker disease BEFREE Our data present, for the first time, preliminary evidence that inherited abnormalities on TP53, MDM2 and BCL2 genes, enrolled in apoptosis pathways, have a pivotal role in differences of outcomes in women and men with CM. 28050764 2017
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.080 Biomarker disease BEFREE Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma. 28092675 2017
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.080 GeneticVariation disease BEFREE Investigation of the effect of MDM2 SNP309 and TP53 Arg72Pro polymorphisms on the age of onset of cutaneous melanoma. 22336942 2012
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.080 GeneticVariation disease BEFREE MDM2 SNP309 and p53 Arg72Pro in cutaneous melanoma: association between SNP309 GG genotype and tumor Breslow thickness. 20535124 2010
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.080 Biomarker disease BEFREE Association of MDM2 SNP309, age of onset, and gender in cutaneous melanoma. 19318491 2009
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.080 AlteredExpression disease BEFREE HDM2 protein overexpression, but not gene amplification, is related to tumorigenesis of cutaneous melanoma. 11606406 2001