MDM4, MDM4 regulator of p53, 4194

N. diseases: 265; N. variants: 9
Disease: Acute monocytic leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia 		0.050 Biomarker disease BEFREE The mRNA expression levels of the full-length of MDM4 (MDM4FL) and short isoform MDM4 (MDM4S) were elevated in CK-AML relative to normal karyotype AML (NK-AML) patients. 25405759 2014
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia 		0.050 AlteredExpression disease BEFREE NBDHEX is not a substrate of either MDR1-Pgp or MRP1 efflux pumps; in fact, it is not only cytotoxic toward the parental HL60 cell line, but also overcomes the MDR phenotype of its HL60/DNR and HL60/ADR variants. 19288261 2009
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia 		0.050 Biomarker disease BEFREE The present results suggest that BCRP, but not MDR1, MRP1 or LRP/MVP is associated with clinical resistant disease in AML. 11986944 2002
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia 		0.050 Biomarker disease BEFREE However, alternative proteins such as the more recently recognized multidrug-associated protein (MRP1), may also contribute to the resistance to anthracyclines and etoposide in AML. 10214864 1999
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia 		0.050 AlteredExpression disease BEFREE In adult acute myeloid leukemia (AML), the weight of the contribution of the combined activity of Pgp and MRP1 to drug resistance is not known. 10419897 1999