Parathyroid Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
This suggests that additional constitutional genetic mutations may contribute to the variation in malignant potential and clinical behavior of parathyroid tumors in MEN1.
|
29097378 |
2017 |
Parathyroid Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
These identified miRNAs could be revealed as prognostic and diagnostic biomarkers for parathyroid tumors to improve the diagnosis of MEN1 neoplasia and other syndromes.
|
28469779 |
2017 |
Parathyroid Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Using a novel genome-wide methylation analysis, we studied tissues from MEN1-parathyroid tumors, Men1 knockout (KO) mice, and Men1 null mouse embryonic fibroblast (MEF) cell lines.
|
26871472 |
2016 |
Parathyroid Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Examples are discussed for each category, and 1 example of each category is named here: 1) total ablation of the entire tissue with effort to replace ablated functions (for example, in C-cell neoplasia of multiple endocrine neoplasia type 2); 2) subtotal ablation with increased likelihood of persistent disease or recurrent disease (for example, in the parathyroid tumors of MEN1); or 3) no ablation of tissue with or without the use of pharmacotherapy (for example, with blockers for secretion of stomach acid in gastrinomas of MEN1).
|
23771922 |
2013 |
Parathyroid Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Menin plays some physiological and pathological roles related to transforming growth factor-beta (TGF-β) signaling pathway in the parathyroid, and it is implicated in the tumorigenesis of parathyroid tumors.
|
22543820 |
2012 |
Parathyroid Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We then examined expression of menin, caspase 8 and cyclin-dependent kinase inhibitors p27(Kip1) and p15(Ink4b) by Western blotting in human parathyroid tumors surgically resected from patients with MEN1 and those with non-hereditary primary hyperparathyroidism.
|
20616437 |
2010 |
Parathyroid Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
This observation correlates with the almost universal occurrence of parathyroid tumors accompanying the inactivation of menin in multiple endocrine neoplasia Type 1 (MEN1) syndrome and the high rate of somatic menin gene mutations seen in sporadic parathyroid adenomas.
|
20175455 |
2009 |
Parathyroid Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Chromosome 11 genomic changes in parathyroid adenoma and hyperplasia: array CGH, FISH, and tissue microarrays.
|
18398822 |
2008 |
Parathyroid Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Therefore, we hypothesized that specific HOX genes were regulated by menin in parathyroid tumor development.
|
18310293 |
2008 |
Parathyroid Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We have identified a germ-line nonsense mutation in the human CDKN1B gene in a MEN1 mutation-negative patient presenting with pituitary and parathyroid tumors.
|
17030811 |
2006 |
Parathyroid Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Somatic mutations of MEN1 gene have also been described in sporadic parathyroid tumors.
|
15754732 |
2004 |
Parathyroid Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Cluster 2, characterized by HRPT2 mutations, was the most striking, suggesting that parathyroid tumors with somatic HRPT2 mutation or tumors developing on a background of germ-line HRPT2 mutation follow pathways distinct from those involved in mutant MEN 1-related parathyroid tumors.
|
15492263 |
2004 |
Parathyroid Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Promoter hypermethylation of RIZ1 was detected in 36% of the parathyroid tumors and was related to LOH at the RIZ1 locus (P=.01), and absence of somatic mutation of the MEN1 gene (P=.044).
|
14668725 |
2003 |
Parathyroid Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Here, we show that loss of Men1 gene function in the parathyroid glands of mice results in histological changes consistent with parathyroid neoplasia as well as systemic hypercalcemia.
|
14633735 |
2003 |
Parathyroid Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Biallelic inactivation by somatic mutations of the MEN1 gene in sporadic parathyroid tumors.
|
11741745 |
2002 |
Parathyroid Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Using microsatellite analysis for LOH at 11q13 and DNA sequencing of the coding exons, the MEN1 gene was studied in 38 parathyroid tumors of patients with sporadic PHPT.
|
12109621 |
2002 |
Parathyroid Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Interest has focused on Smad3 as a candidate endocrine tumor suppressor gene because 1) it is localized to 15q and 2) it encodes a TGF beta signaling molecule that has been identified as a binding partner of the multiple endocrine neoplasm type 1 gene product menin, itself involved in enteropancreatic and parathyroid neoplasia.
|
12161532 |
2002 |
Parathyroid Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The molecular genetic techniques of comparative genomic hybridization (CGH), loss of heterozygosity (LOH), and MEN1 mutation analysis were performed on a series of five patients with multiglandular PHPT, each of which had two parathyroid tumors removed.
|
12368203 |
2002 |
Parathyroid Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Our data indicated that the majority of lithium-associated parathyroid tumors do not contain gross chromosomal alterations and suggest that in most cases the tumorigenic pathway is independent of MEN1 and genes at 1p34.3-pter and 1q21-q32.
|
11980616 |
2002 |
Parathyroid Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
To date, somatic MEN1 mutations are reported in about 20% of sporadic parathyroid tumors.
|
10915003 |
2000 |
Parathyroid Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Six novel MEN1 gene mutations in sporadic parathyroid tumors.
|
11058905 |
2000 |
Parathyroid Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These observations indicate that somatic inactivation of the MEN1 gene contributes to the pathogenesis of uremia-associated parathyroid tumors, but its role in this disease appears to be very limited.
|
11095441 |
2000 |
Parathyroid Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Germ-line MEN1 gene analysis can distinguish heritable from nonheritable parathyroid tumors, and MEN1 gene evaluation of patients with apparently sporadic parathyroid tumor is recommended before parathyroid surgery.
|
11034102 |
2000 |
Parathyroid Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Menin messenger ribonucleic acid was strongly expressed on RT-PCR analysis in the parathyroid tumors from both PHP and SHP.
|
10902816 |
2000 |
Parathyroid Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Occasionally, the MEN1 gene mutation sites in sporadic parathyroid tumors are identical to those reported in tumors from patients with familial or sporadic MEN 1.
|
10715991 |
2000 |