|
Weight Gain
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice.
|
19030233 |
2008 |
|
3-Methylglutaconic aciduria type 2
|
0.200 |
Biomarker
|
disease |
MGD |
Expression of Peg1 (Mest) in the developing mouse heart: involvement in trabeculation.
|
12242721 |
2002 |
|
3-Methylglutaconic aciduria type 2
|
0.200 |
Biomarker
|
disease |
MGD |
Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest.
|
9771709 |
1998 |
|
Schizophrenia, Childhood
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
De novo variants in sporadic cases of childhood onset schizophrenia.
|
26508570 |
2016 |
|
Russell-Silver syndrome
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
However, several observations indicate that molecular alterations of the genomically imprinted MEST region in 7q32.2 are associated with growth retardation and a phenotype reminiscent to SRS.
|
26663145 |
2016 |
|
Russell-Silver syndrome
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The exclusion of isolated imprinting defects in our study population shows that this type of epimutation at the PEG1/MEST locus in 7q31 does not play a relevant role in SRS.
|
18585117 |
2008 |
|
Russell-Silver syndrome
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Silver-Russell syndrome in a girl born after in vitro fertilization: partial hypermethylation at the differentially methylated region of PEG1/MEST.
|
17450433 |
2007 |
|
Russell-Silver syndrome
|
0.060 |
Biomarker
|
disease |
BEFREE |
As a Silver-Russell syndrome (SRS) locus has been proposed to be located to a region near MEST and to be involved in imprinting, CPA4 would have been a candidate gene for SRS.
|
12552318 |
2003 |
|
Russell-Silver syndrome
|
0.060 |
Biomarker
|
disease |
BEFREE |
These findings suggest that PEG1/MEST can be excluded as a major determinant of SRS.
|
11754049 |
2001 |
|
Russell-Silver syndrome
|
0.060 |
Biomarker
|
disease |
BEFREE |
These findings strongly argue against a role of PEG1/MEST in the majority of Silver-Russell syndrome cases.
|
9781054 |
1998 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Furthermore, overexpression of MEST could restore the tumour-suppressed and the Wnt/β-catenin pathway inactivated effects of ZFP57.
|
30787268 |
2019 |
|
Obesity
|
0.040 |
Biomarker
|
disease |
BEFREE |
Highly variable expression of mesoderm-specific transcript (Mest) in adipose tissue among genetically homogeneous mice fed an obesogenic diet, and its positive association with fat mass expansion, suggests that Mest is an epigenetic determinant for the development of obesity.
|
29058774 |
2018 |
|
Obesity
|
0.040 |
Biomarker
|
disease |
BEFREE |
Since inactivation of Mest in mice has minimal additional effects aside from reduction of ATE, an intervention that mitigates MEST function in adipocytes is a plausible strategy to obviate obesity and type-2-diabetes.
|
28640866 |
2017 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Profiling MEST and RXRγ for curcumin and CBB1007, respectively, indicated an inability of curcumin and CBB1007 in restricting residual tumor regenerative capabilities.
|
26130461 |
2015 |
|
Neoplasms
|
0.040 |
PosttranslationalModification
|
group |
BEFREE |
The levels of miR-335/MEST methylation were significantly higher in 18 (90%) out of 20 primary HCC tumors, compared to their non-tumor tissue counterparts (P<0.001).
|
23229728 |
2013 |
|
Obesity
|
0.040 |
Biomarker
|
disease |
BEFREE |
Specifically, epigenetic malprogramming of MEST may contribute to obesity predisposition throughout life.
|
23209187 |
2013 |
|
Obesity
|
0.040 |
Biomarker
|
disease |
BEFREE |
Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner.
|
17182038 |
2007 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
Biomarker
|
disease |
BEFREE |
Recently, frequent loss of imprinting (LOI) of PEG1/MEST has been reported in lung adenocarcinomas.
|
15547750 |
2004 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Taking advantage of our previous study identifying lung adenocarcinomas displaying biallelic expression of the imprinted gene MEST, we investigated the validity of a method of allelic discrimination in a real-time PCR assay using allele-specific probes.
|
12851725 |
2003 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
Biomarker
|
disease |
BEFREE |
Putative loss of imprinting (LOI) of PEG1/MEST has subsequently also been implicated in the aetiology of lung adenocarcinomas and colon cancer.
|
12023987 |
2002 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
Biomarker
|
disease |
BEFREE |
These findings indicated that independent deregulation took place in imprinted genes and suggested that aberrant imprinting of IGF2 and MEST was involved in the development of lung adenocarcinoma.
|
11536368 |
2001 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
LOI of IGF2 and PEG1/MEST was also observed in colorectal mucosa from almost all the patients with LOI in tumor tissue.
|
10891541 |
2000 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Also, MEST induces metastatic potential of breast cancer through induction of the EMT-TFs-mediated EMT program.
|
30903102 |
2019 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
ZFP57-MEST and the Wnt/β-catenin pathway axis are involved in breast tumorigenesis, which may represent a potential diagnostic biomarker, and provide a new insight into a novel therapeutic strategy for breast cancer patients.
|
30787268 |
2019 |
|
Male infertility
|
0.030 |
PosttranslationalModification
|
phenotype |
BEFREE |
The meta-analytic approach demonstrated that male infertility is associated with altered sperm methylation at H19, MEST, and SNRPN.
|
28718528 |
2017 |