MEST, mesoderm specific transcript, 4232

N. diseases: 59; N. variants: 2
Disease: Obesity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.040 Biomarker disease BEFREE Highly variable expression of mesoderm-specific transcript (Mest) in adipose tissue among genetically homogeneous mice fed an obesogenic diet, and its positive association with fat mass expansion, suggests that Mest is an epigenetic determinant for the development of obesity. 29058774 2018
CUI: C0028754
Disease: Obesity
Obesity 		0.040 Biomarker disease BEFREE Since inactivation of Mest in mice has minimal additional effects aside from reduction of ATE, an intervention that mitigates MEST function in adipocytes is a plausible strategy to obviate obesity and type-2-diabetes. 28640866 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.040 Biomarker disease BEFREE Specifically, epigenetic malprogramming of MEST may contribute to obesity predisposition throughout life. 23209187 2013
CUI: C0028754
Disease: Obesity
Obesity 		0.040 Biomarker disease BEFREE Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner. 17182038 2007