|
Lung Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Our model-based analysis demonstrates compelling evidence for both location and neighbour dependence in the process of aberrant DNA methylation of this MGMT promoter CpG island in lung tumours.
|
23911575 |
2013 |
|
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Association between lung cancer risk and single nucleotide polymorphisms in the first intron and codon 178 of the DNA repair gene, O6-alkylguanine-DNA alkyltransferase.
|
17957803 |
2008 |
|
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
To further verify whether a different prevalence of MGMT promoter methylation is observed in lung tumors with a different tumor histology, gender, and smoking status, 220 lung tumors were collected to evaluate the status of MGMT promoter methylation and p53 mutation using methylation-specific PCR (MSP) and direct sequencing, respectively.
|
18712569 |
2008 |
|
Lung Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
In conclusion, MGMT promoter methylation modulated by p53 status could partially promote p53 mutation occurrence in advanced lung tumors.
|
18555750 |
2008 |
|
Lung Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
To further verify whether a different prevalence of MGMT promoter methylation is observed in lung tumors with a different tumor histology, gender, and smoking status, 220 lung tumors were collected to evaluate the status of MGMT promoter methylation and p53 mutation using methylation-specific PCR (MSP) and direct sequencing, respectively.
|
18712569 |
2008 |
|
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Genetic variants in MGMT and risk of lung cancer in Southeastern Chinese: a haplotype-based analysis.
|
17285603 |
2007 |
|
Lung Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we applied methylation-specific polymerase chain reaction to compare the frequencies of the methylated promoter of p16 and O6-methylguanine-DNA methyltransferase (MGMT) genes in lung tumors from 122 patients with non-small cell lung cancer, including 81 smokers and 41 never-smokers.
|
16533425 |
2006 |
|
Lung Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
LHGDN |
Here, we applied methylation-specific polymerase chain reaction to compare the frequencies of the methylated promoter of p16 and O6-methylguanine-DNA methyltransferase (MGMT) genes in lung tumors from 122 patients with non-small cell lung cancer, including 81 smokers and 41 never-smokers.
|
16533425 |
2006 |
|
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
O6-alkylguanine-DNA alkyltransferase gene polymorphisms and the risk of primary lung cancer.
|
16385589 |
2006 |
|
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Polymorphisms in TDG and MGMT genes - epidemiological and functional study in lung cancer patients from Poland.
|
15225156 |
2004 |
|
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Lack of association between Caucasian lung cancer risk and O6-methylguanine-DNA methyltransferase-codon 178 genetic polymorphism.
|
15140540 |
2004 |
|
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer.
|
11719438 |
2001 |
|
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Moreover, a reduction in the frequency of K-ras mutations in lung tumors was found in MGMT transgenic mice (6.7 versus 50% in non-transgenic mice).
|
10069465 |
1999 |