|
Hereditary nonpolyposis colorectal carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Mechanisms of inactivation of MLH1 in hereditary nonpolyposis colorectal carcinoma: a novel approach.
|
17260015 |
2007 |
|
Hereditary nonpolyposis colorectal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The members of gastric cancer families from northern China may have similar genetic background of hMLH1 gene mutation as those of hereditary nonpolyposis colorectal carcinoma.
|
15918206 |
2005 |
|
Hereditary nonpolyposis colorectal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The current data showed instead that the BRAF V599E mutation was associated only with a subgroup of colorectal carcinomas with MSI that were obtained from older patients without hereditary nonpolyposis colorectal carcinoma and showed epigenetic silencing of hMLH1.
|
16015629 |
2005 |
|
Hereditary nonpolyposis colorectal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Defects in DNA mismatch-repair genes MLH1 and MSH2 reported primarily in hereditary nonpolyposis colorectal carcinoma are present in many sporadic tumors, including malignant melanomas.
|
15619215 |
2004 |
|
Hereditary nonpolyposis colorectal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Forty-eight hereditary nonpolyposis colorectal carcinoma (HNPCC) families for which a tumor sample was available were evaluated for the presence of germ-line mutations in MSH2 and MLH1, tumor microsatellite instability (MSI), and where possible, expression of MSH2 and MLH1 in tumors by immunohistochemistry.
|
12067992 |
2002 |
|
Hereditary nonpolyposis colorectal carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor.
|
12124320 |
2002 |
|
Hereditary nonpolyposis colorectal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Endometrial carcinoma is the most commonly associated extracolonic malignancy in hereditary nonpolyposis colorectal carcinoma in which germ line mutations in DNA mismatch repair genes, particularly in MSH2 and MLH1, are known to cause this syndrome.
|
11391585 |
2001 |
|
Hereditary nonpolyposis colorectal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genomic instability at short tandem repeats in the DNA, referred to as microsatellite instability (MSI) is the hallmark of hereditary nonpolyposis colorectal carcinoma (HNPCC) caused by mutations in DNA mismatch-repair genes, mostly hMLH1 and hMSH2.
|
11221877 |
2001 |
|
Hereditary nonpolyposis colorectal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hereditary nonpolyposis colorectal carcinoma (HNPCC) is due primarily to inherited mutations in two mismatch repair genes, MSH2 and MLH1, whereas germ-line mutations in other mismatch repair genes are rare.
|
10537275 |
1999 |
|
Hereditary nonpolyposis colorectal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Saccharomyces cerevisiae pms2 mutations are alleles of MLH1, and pms2-2 corresponds to a hereditary nonpolyposis colorectal carcinoma-causing missense mutation.
|
8649412 |
1996 |
|
Hereditary nonpolyposis colorectal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Structure of the human MLH1 locus and analysis of a large hereditary nonpolyposis colorectal carcinoma kindred for mlh1 mutations.
|
7812952 |
1995 |
|
Hereditary nonpolyposis colorectal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hereditary nonpolyposis colorectal carcinoma (HNPCC) is a major cancer susceptibility syndrome known to be caused by inheritance of mutations in genes such as hMSH2 and hMLH1, which encode components of a DNA mismatch repair system.
|
7713503 |
1994 |