|
Leukemia, Myelocytic, Acute
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that MLLT1 and AFDN account for the majority (63%) of KMT2A gene partners in pediatric/young adult T-ALL/LBL, while no KMT2A/AFF1 or KMT2A/MLLT3 fusions were observed despite their common identification in B-ALL and acute myeloid leukemia, respectively.
|
30203571 |
2018 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our findings demonstrate the unique oncogenic role for SHARP1 in MLL-AF6 AML.
|
29692408 |
2018 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
Biomarker
|
disease |
BEFREE |
Here, we first showed the underexpression of KDM3B in acute myeloid leukemia (AML) patients and AML cell lines with MLL-AF6/9 or PML-RARA translocations.
|
28540746 |
2018 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
Biomarker
|
disease |
BEFREE |
Here, we report the first case in which a dominant Philadelphia chromosome-positive subclone was detected upon relapse in a formerly Philadelphia chromosome-negative MLL-AF6(+) AML.
|
25401297 |
2015 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
Biomarker
|
disease |
BEFREE |
A high frequency of MLLT4 in our study was due to the high proportion of acute myeloid leukemia cases in pediatric and adult patients.
|
24612538 |
2014 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
Biomarker
|
disease |
BEFREE |
Altogether, these data point to a novel role of the MLL-AF6 chimera and show that its gene partner, AF6, is crucial in AML development.
|
24695851 |
2014 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
High EVI1 expression occurs in AMLs expressing the MLL-AF6, -AF9, -AF10, -ENL, or -ELL fusion genes.
|
22553314 |
2012 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
[Application of reverse transcription-multiplex nested PCR to detect MLL rearrangement in AML-M4/M5].
|
16086288 |
2005 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
Biomarker
|
disease |
BEFREE |
This is the first report of MRD and the probability of graft-versus-leukemia effects following BMT in AML patients who are MLL-AF6 fusion transcript positive.
|
11999359 |
2002 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
Biomarker
|
disease |
BEFREE |
Monitoring of minimal residual disease in patients with MLL-AF6-positive acute myeloid leukaemia by reverse transcriptase polymerase chain reaction.
|
10886213 |
2000 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Reverse transcriptase-polymerase chain reaction (RT-PCR) using an MLL sense primer and an AF6 antisense primer detected the MLL/AF6 fusion cDNA from three leukemia patients with the t(6;11) [two AML and one T-acute lymphoblastic leukemia (ALL)] and one cell line.
|
8703846 |
1996 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation.
|
8242616 |
1993 |