|
Squamous cell carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
These results suggested that MMP1 may be pivotal to the transition from normal skin to premalignant lesions to SCC, thus representing a potential therapeutic target gene of diagnosis and prevention in SCC.
|
29249121 |
2019 |
|
Squamous cell carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In addition, the combined effects of IL-8 (rs4073), MMP-1 (rs2071230 and rs470558) and MMP-13 (rs2252070) with environmental carcinogens, such as tobacco and alcohol, are related to increased risk for oral and oropharyngeal SCC development.
|
31525531 |
2019 |
|
Squamous cell carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
By comparison to other cancer studies, MMP1 and IL8 appeared to be potential marker genes for the development of SCCs.
|
31084699 |
2019 |
|
Squamous cell carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Additionally, differential methylation or expression of several genes, including fibroblast activation protein α (FAP), interferon α inducible protein 27 (IFI27), laminin subunit γ2 (LAMC2), matrix metallopeptidase 1 (MMP1), serine peptidase inhibitor Kazal‑type 5 (SPINK5) and zinc finger protein 662 (ZNF662), was significantly associated with the survival of OSCC patients, and their differential expression in OSCC patients was further confirmed by reverse transcription‑quantitative polymerase chain reaction in OSCC and normal oral cell lines.
|
30226546 |
2018 |
|
Squamous cell carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The matrix metalloproteinase gene (MMP-1) variant, rs5854, was associated with oral SCCA; participants with even one variant allele were more likely to have oral SCCA (ORadjusted = 2.62, 95% CI 1.05-6.53) compared to people with ancestral alleles.
|
24278120 |
2013 |
|
Squamous cell carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Salivary concentrations of MMP1 and MMP3 in OSCC patients (33 stage I/II, 26 stage III/IV) were 6.2 times (95% CI: 3.32-11.73) and 14.8 times (95% CI: 6.75-32.56) higher, respectively, than in controls, and displayed an increasing trend with higher stage disease.
|
21960692 |
2011 |
|
Squamous cell carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Expression of MMP-1 and -13 was analyzed in esophageal cancer (n = 41 EAC with BE, n = 19 EAC without BE, and n = 10 esophageal squamous-cell carcinomas, ESCC), furthermore in BE without intraepithelial neoplasia (IN) (n = 18), and the cell line OE-33.
|
20946664 |
2010 |
|
Squamous cell carcinoma
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
The 2G allele of promoter region of matrix metalloproteinase-1 as an essential pre-condition for the early onset of oral squamous cell carcinoma.
|
17919326 |
2007 |
|
Squamous cell carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The 2G allele of promoter region of matrix metalloproteinase-1 as an essential pre-condition for the early onset of oral squamous cell carcinoma.
|
17919326 |
2007 |
|
Squamous cell carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of matrix metalloproteinase-1 (-1607 1G/2G) polymorphism with increased risk for oral squamous cell carcinoma.
|
17352267 |
2007 |
|
Squamous cell carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances oral squamous cell carcinoma susceptibility in a Chinese population.
|
16256416 |
2006 |
|
Squamous cell carcinoma
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
No association of the matrix metalloproteinase 1 promoter polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in northern China.
|
15832405 |
2005 |
|
Squamous cell carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In this study, the MMP-1 polymorphism was assessed in 135 high-grade squamous intraepithelial lesions (HSILs) and 197 invasive squamous cell carcinomas (SCCs), and in age-matched controls, by capillary electrophoresis.
|
15661214 |
2005 |
|
Squamous cell carcinoma
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Correlation between functional genotypes in the matrix metalloproteinases-1 promoter and risk of oral squamous cell carcinomas.
|
15200479 |
2004 |
|
Squamous cell carcinoma
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Single nucleotide polymorphisms in MMP1 and MMP3 gene promoters as risk factor in head and neck squamous cell carcinoma.
|
15274394 |
2004 |
|
Squamous cell carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
MMP-1 and -9 levels were significantly higher in the SCCs compared with all oral dysplasias (P = 0.004 and P = 0.01, respectively).
|
15475433 |
2004 |
|
Squamous cell carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Expression of collagenase-1 (MMP-1), collagenase-3 (MMP-13) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in laryngeal squamous cell carcinomas.
|
12739032 |
2003 |
|
Squamous cell carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Induction of matrix metalloproteinase 1 by collagen was also observed in two other malignant HaCaT-ras clones as well as in 2/2 primary squamous cell carcinoma lines.
|
11168802 |
2001 |
|
Squamous cell carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We measured the production levels of seven different matrix metalloproteinases (MMP-1, 2, 3, 7, 8, 9 and 13) and two tissue inhibitors of metalloproteinases (TIMP-1 and 2) in the homogenates of human oral squamous cell carcinomas and control normal squamous epithelia by the corresponding sandwich enzyme immunoassay systems.
|
11235994 |
2000 |
|
Squamous cell carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Moreover, MMP-1 expression could be an early event in the development of SCC, and AK demonstrating MMP-1 mRNA, might be in a more advanced dysplastic state, progressing to SCC.
|
10362121 |
1999 |
|
Squamous cell carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Interstitial collagenase gene expression in oral squamous cell carcinoma.
|
1323216 |
1992 |
|
Squamous cell carcinoma
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|