Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gingival biopsies from periodontally healthy and periodontitis individuals were analyzed for the presence of F. alocis and MMP-1 by RT-PCR.
|
31444694 |
2019 |
Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Diabetic conditions such as HG induce IL-1β and sIL-6R production from macrophages in inflammatory periodontal tissues and may exacerbate the periodontitis synergistically via MMP-1 production from HGFs.
|
30355945 |
2018 |
Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
I found that macrophage-like cells, fibroblast-like cells, vascular endothelial cells and gingival epithelial cells were stained more intensely for MMP-1 and were observed more frequently in the periodontitis affected group than in the control group.
|
28682139 |
2017 |
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results revealed that although studies of the association between MMP-8 -799 C/T variant and the susceptibility to periodontitis have not yielded consistent results, MMP-1 (-1607 1G/2G, -519 A/G, and -422 A/T), MMP-2 (-1575 G/A, -1306 C/T, -790 T/G, and -735 C/T), MMP-3 (-1171 5A/6A), MMP-8 (-381 A/G and +17 C/G), MMP-9 (-1562 C/T and +279 R/Q), and MMP-12 (-357 Asn/Ser), as well as MMP-13 (-77 A/G, 11A/12A) SNPs are not related to periodontitis risk.Conclusions.
|
27194818 |
2016 |
Periodontitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Statin intake is associated with MMP-1 level in gingival crevicular fluid of patients with periodontitis.
|
26988924 |
2016 |
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The pooled results showed significant association between periodontitis susceptibility and MMP-1 g.-1607dupG polymorphism in homozygote (2G/2G versus 1G/1G, OR = 1.50, 95% CI = 1.02-2.20) and dominant model analysis (2G/2G+2G/1G versus 1G/1G, OR = 1.28, 95% CI = 1.04-1.57).
|
23527212 |
2013 |
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The current study demonstrated that the Matrix metalloproteinase-1-1607 1G-to-2G polymorphism was associated with susceptibility to periodontitis, apparently, severe periodontitis.
|
23500593 |
2013 |
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis demonstrates a lack of association between the TLR2 Arg753Gln, TLR4 Asp299Gly, Thr399Ile, MMP-9 -1562 C/T polymorphisms and periodontitis, but shows an association between the MMP-1 -1607 G2G2 genotype and periodontitis in Asians.
|
23653009 |
2013 |
Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nonsmoker subjects with periodontitis had statistically significantly higher MMP-1, lower MMP-9 and TIMP-1 expression and higher MMP-1/TIMP-1 ratio than smokers; and higher MMP-8 expression and MMP-8/TIMP-1 and MMP-1/TIMP-1 ratios than healthy nonsmokers.
|
21732946 |
2011 |
Periodontitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data demonstrate a limited role for MMP1-1607 SNP in periodontitis, where the extensive chronic antigenic challenge exposure overcomes the genetic control and plays a major role in the determination of MMP-1 expression.
|
19659894 |
2009 |
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
On the basis of the results, no significant association is found for the MMP-1 -1607 1G/2G polymorphism with susceptibility to periodontitis.
|
19040577 |
2008 |
Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ratios of MMP-1/TIMP-2 (P <0.01), MMP-3/TIMP-2 (P <0.05), MMP-9/TIMP-2 (P <0.05), and MMP-1/TIMP-3 (P <0.01) from periodontitis lesions were significantly higher than those in the control tissues.
|
18166107 |
2008 |
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of polymorphisms showed no differences in distribution of the -1607 1G/2G and -519 A/G variants in the MMP-1 gene between the healthy and periodontitis group (p > 0.05).
|
16899023 |
2006 |
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data did not support the hypothesis that MMP-1 and/or MMP-3 gene promoter polymorphisms influenced the susceptibility to periodontitis in Japanese patients, indicating MMP-1 and MMP-3 expressions were regulated by complex processes such as cytokine network in periodontal disease rather than gene polymorphisms.
|
15312099 |
2004 |
Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sections of tissue biopsies obtained from advanced, destructive periodontitis were compared with minimally inflamed periodontal tissues in relation to the distribution of type I (interstitial) collagenase.
|
8774491 |
1996 |