MMP1, matrix metallopeptidase 1, 4312

N. diseases: 589; N. variants: 19
Disease: Tuberculosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.100 AlteredExpression disease BEFREE Within the TB-DM group, those known to be diabetic before incident TB (KDM) exhibited significantly higher levels of MMP-1, - 2, - 10 and - 12 at baseline and of MMP-1 and -3 post-treatment compared to those newly diagnosed with DM (NDM). 30045688 2018
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.100 Biomarker disease BEFREE We also tested whether inhibition of endogenous matrix metalloproteinase-1 (MMP-1) may inhibit cavitation during tuberculosis. 29554286 2018
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.100 Biomarker disease BEFREE MMP-1 plays a curial role in extracellular matrix degradation during the progression of tuberculosis. 28129430 2017
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.100 AlteredExpression disease BEFREE In mice, transgenic expression of human matrix metalloproteinase 1 causes caseous necrosis, the pathological hallmark of human tuberculosis. 25676469 2015
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.100 Biomarker disease BEFREE Targeted siRNA studies identified the p110α isoform as key causing 5-fold increase in TB network-dependent MMP-1 secretion to 4900 ± 1100 pg/ml. 24076964 2014
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.100 AlteredExpression disease BEFREE Monocyte-microglial network-dependent MMP-1 and MMP-3 gene expression and secretion are dependent upon p38 MAPK in tuberculosis. p38 is therefore a potential target for adjuvant therapy in CNS TB. 23978194 2013
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.100 Biomarker disease BEFREE STAT3, p38 MAPK, and NF-kappaB drive unopposed monocyte-dependent fibroblast MMP-1 secretion in tuberculosis. 19915152 2010
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.100 GeneticVariation disease BEFREE We report that a joint effect between the -2518 MCP-1 genotype GG and the -1607 MMP-1 genotype 2G/2G consistently increases the odds of developing TB 3.59-fold in Mexicans and 3.9-fold in Peruvians. 20111728 2010
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.100 AlteredExpression disease BEFREE Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and Activator Protein-1-dependent monocyte networks. 20483790 2010
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.100 AlteredExpression disease BEFREE In summary, p-aminosalicyclic acid decreases MMP-1 activity by inhibiting a p38 MAPK-PG signaling cascade, suggesting that this pathway is a therapeutic target to reduce inflammatory tissue destruction in tuberculosis. 19380835 2009
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.100 GeneticVariation disease BEFREE 1G genotypes of MMP-1 polymorphism, containing at least one 1G allele, were associated with the presence of endobronchial TB. 17996495 2008
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.100 AlteredExpression disease BEFREE MMP-1 but not MMP-7 expression and secretion are relatively M. tuberculosis specific, are not upregulated by tuberculosis-associated cytokines, and are prostaglandin dependent. 16141443 2005
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.100 GeneticVariation disease BEFREE Although MMP-1 polymorphism was not associated with onset risk of sarcoidosis and tuberculosis, the clinical characteristics of both diseases were affected by this polymorphism. 15127970 2004