MMP1, matrix metallopeptidase 1, 4312

N. diseases: 589; N. variants: 19
Disease: Chronic Periodontitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis 		0.100 AlteredExpression disease BEFREE MMP-1 expression and the MMP-1/TIMP-1, MMP-2/TIMP-1, MMP-8/TIMP-1, MMP-9/TIMP-1, MMP-1/TIMP-2 and MMP-2/TIMP-2 ratios were higher in the DMChP group than in the ChP and SChP groups (p < 0.05). 27363729 2017
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis 		0.100 GeneticVariation disease BEFREE Matrix metalloproteinase-1 promoter -1607 1G/2G (rs1799750) polymorphism may have no effect on the disease susceptibility of CP in Caucasian, Asian and Brazilian mixed populations. 24134675 2013
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis 		0.100 GeneticVariation disease BEFREE MMP-1-1067 2G, MMP-3-1171 6A, MMP-9-1562 T and IL-8-251 A allele are associated with decreased susceptibility to CP in Chinese population. 22819245 2012
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis 		0.100 GeneticVariation disease BEFREE No association was found between the MMP1-1607 polymorphism and CP or ESRD. 22401717 2012
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis 		0.100 AlteredExpression disease BEFREE Thirty-six gingival samples were collected and treated for the determination of RAGE, NF-κB, and MMP-1 mRNA level in gingival connective tissues from the participants with chronic periodontitis, diabetes-associated periodontitis, and healthy controls. 21563948 2012
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis 		0.100 GeneticVariation disease BEFREE Association of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) and cyclooxygenase-2 gene polymorphisms and their proteins with chronic periodontitis. 21481333 2011
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis 		0.100 AlteredExpression disease BEFREE This study investigated the influence of genetic (MMP1-1607 SNP), microbial (Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Actinobacillus actinomycetemcomitans) and inflammatory [tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta)] factors on the determination of MMP-1 mRNA levels in periodontal tissues of non-smoker chronic periodontitis (CP, N=178) and control (C, N=190) groups. 19659894 2009
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis 		0.100 GeneticVariation disease LHGDN Effect of MMP-1 promoter polymorphisms on GCF MMP-1 levels and outcome of periodontal therapy in patients with severe chronic periodontitis. 18710412 2008
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis 		0.100 GeneticVariation disease BEFREE These data suggest that the -1607 2G polymorphic allele of the MMP-1 gene could be associated with susceptibility to severe CP in the Turkish population. 18710412 2008
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis 		0.100 GeneticVariation disease BEFREE The aim of this study was to examine the association between MMP-1 -1607 1G/2G polymorphism and chronic periodontitis susceptibility in a Turkish population. 19040577 2008
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis 		0.100 GeneticVariation disease BEFREE Genetic polymorphisms in the MMP-1 and MMP-3 gene may contribute to chronic periodontitis in a Brazilian population. 16899023 2006
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis 		0.100 GeneticVariation disease BEFREE This study suggests that a single nucleotide polymorphism in the MMP-1 promoter region of -1607 bp may be associated with severe chronic periodontitis in a Chinese population. 16774538 2006
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis 		0.100 GeneticVariation disease LHGDN This study suggests that a single nucleotide polymorphism in the MMP-1 promoter region of -1607 bp may be associated with severe chronic periodontitis in a Chinese population. 16774538 2006
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis 		0.100 GeneticVariation disease BEFREE Genetic variations in the matrix metalloproteinase-1 promoter and risk of susceptibility and/or severity of chronic periodontitis in the Czech population. 15257748 2004
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis 		0.100 GeneticVariation disease LHGDN These results show that a polymorphism in the promoter region of MMP-1 gene is associated with the severe chronic periodontitis phenotype in non-smokers. 12622858 2003
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis 		0.100 GeneticVariation disease BEFREE These results show that a polymorphism in the promoter region of MMP-1 gene is associated with the severe chronic periodontitis phenotype in non-smokers. 12622858 2003