Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Steady-state levels of transcripts encoding extracellular matrix proteins, MMP-2 (72-kDa collagenase IV), MMP-9 (92-kDa collagenase type IV), TIMP-1 and TIMP-2 were elevated in the majority of pancreatic-cancer tissue samples as compared to control pancreatic tissue.
|
7635566 |
1995 |
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of MMP2, -7, and -11 was greater in pancreatic carcinoma than in normal pancreas (P < 0.01).
|
9349239 |
1997 |
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pancreatic cancer is no exception; MMP-2 and MMP-9 show high levels of expression in clinical and experimental models.
|
12167581 |
2002 |
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we tested the hypothesis that the COX-2 product prostaglandin E(2) (PGE(2)) increases cellular invasive potential by inducing matrix metalloproteinase-2 (MMP-2) expression and activity through an extracellular signal-regulated kinase (ERK)/Ets-1-dependent mechanism in pancreatic cancer.
|
15492268 |
2004 |
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumor-associated trypsinogen (TAT), urokinase-type plasminogen activator (u-PA), matrix metalloproteinase-2 (MMP-2), and MMP-9 each play a dominant role in the degradation of extracellular matrix (ECM) during the invasion process of pancreatic cancer.
|
15257104 |
2004 |
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Glucose transporter-1 gene expression is associated with pancreatic cancer invasiveness and MMP-2 activity.
|
15349101 |
2004 |
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Summary, our studies indicate for the first time that NRAGE could suppress metastasis of melanoma and pancreatic cancer probably through downregulation of MMP-2.
|
17140727 |
2007 |
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Suppression of matrix metalloproteinase-2 via RNA interference inhibits pancreatic carcinoma cell invasiveness and adhesion.
|
19266599 |
2009 |
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that BMP signaling, through Smad1 induction and upregulation of MMP-2, is an important mediator of pancreatic cancer invasiveness and a potential therapeutic target for treating this deadly disease.
|
19056927 |
2009 |
Pancreatic carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Activation and blocking of the Stat3 signaling pathway can affect invasion ability and expression of the VEGF and MMP-2 genes in pancreatic cancer cells.
|
20482858 |
2010 |
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, establishment of pancreatic cancer in mice exposed to chronic stress was accompanied by up-regulation of the expression of MMP-2, MMP-9, and VEGF, mediated by a HIF- 1α-dependent β-AR signaling pathway.
|
23745588 |
2013 |
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, analysis of SDF-1α, CXCR4 and MMP-2 expression in pancreatic cancer and adjacent tissue samples from ten patients revealed that all three proteins are overexpressed in human pancreatic cancer.
|
23712777 |
2013 |
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results demonstrated that DAPK1 gene over-expression can suppress the proliferation, migration, and invasion of carcinoma of pancreas BxPC-3 cell line, and the possible mechanisms may be correlated to induction of mitochondria-mediated apoptosis, down-regulations of MMP-2 and VEGF, up-regulations of PEDF, through the PI3K/Akt and ERK pathways.
|
25550789 |
2014 |
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the present study reveals that the increased expression of OCT4 is correlated with the differentiation of pancreatic cancer, while knockdown of OCT4 suppresses the growth and invasion of pancreatic cancer cells through inhibition of AKT pathway‑mediated PCNA and MMP‑2 expression, suggesting that OCT4 might serve as a potential therapeutic target for the treatment of pancreatic cancer.
|
25017645 |
2014 |
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
M-CTX-Fc decreased MMP-2 release into the media of PANC-1 cells in a dose-dependent manner.
|
24511528 |
2014 |
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data indicate that overexpressed miR-221/222 may play an oncogenic role in pancreatic cancer by inducing the expression of MMP-2 and MMP-9, thus leading to cancer cell invasion.
|
25883224 |
2015 |
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of miR-29c suppresses pancreatic cancer liver metastasis in a nude mouse orthotopic implantation model. miR-29c expression was associated with metastasis and pancreatic cancer patient survival. miR-29c plays an important role in mediating pancreatic cancer metastasis to the liver by targeting MMP2.
|
25863127 |
2015 |
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of TM4SF1 inhibited the migration and invasion of pancreatic cancer cells by regulating the expression and activity of MMP-2 and MMP-9, which suggests that TM4SF1 may play a significant role in metastasis in pancreatic cancer.
|
27459514 |
2016 |
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Transient Receptor Potential Melastatin 7 Channel Regulates Pancreatic Cancer Cell Invasion through the Hsp90α/uPA/MMP2 pathway.
|
28284058 |
2017 |
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Elevated MMP-2 levels were observed in blood of pancreatic cancer patients which correlated with its tissue expression.
|
29355139 |
2017 |
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of MMP-2 and MMP-9 is associated with angiogenesis in pancreatic cancer.
|
26866436 |
2018 |
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Rosmarinic inhibits cell proliferation, invasion and migration via up-regulating miR-506 and suppressing MMP2/16 expression in pancreatic cancer.
|
31060006 |
2019 |
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TSPAN1 upregulates MMP2 to promote pancreatic cancer cell migration and invasion via PLCγ.
|
30720116 |
2019 |
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Presented findings suggest higher usefulness of TIMP-2 than MMP-2 as potential biomarker in the diagnosis of PC patients, however more studies on large population are needed to support our results.
|
30719232 |
2019 |
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the anti-metastasis role of CSN5 silence was reversed by MMP2 overexpression, whereas knockdown of MMP2 decreased PC metastasis driven by upregulation of CSN5.
|
30352219 |
2019 |