|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, Pin1 inhibition also resulted in decreased phosphorylation of Akt and repressed expression of C-Jun N-terminal kinase and pro-matrix metalloproteinase 2, which were associated closely with the development of melanoma.
|
23067222 |
2013 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Concomitant decreases in vascular endothelial growth factor, interleukin-8, and matrix metalloproteinase-2 expression levels, as well as decreased blood vessel density (CD31), were found in tumor samples from PAR-1 siRNA-treated mice, suggesting that PAR-1 is a regulator of melanoma cell growth and metastasis by affecting angiogenic and invasive factors.
|
18974154 |
2008 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Melanoma A-2058 demonstrated strong expression of MMP-2 and slight expression of MMP-9.
|
28440509 |
2017 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Most melanoma cell lines and cultured normal melanocytes produced high levels of matrix metalloproteinase-2.
|
16718267 |
2006 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To better understand the potential impact of these mutant amino acids on protease function and cancer progression, we established a bioinformatics approach to assessing the impact of melanoma mutants, among a previously defined set of extracellular matrix (ECM) structural proteins, on the sensitivity of matrix metalloproteinase-2 (MMP2), extensively associated with melanoma.
|
31019293 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
For instance, a RAR alpha antagonist suppressed MMP-1 and MMP-2 synthesis in the melanoma cell line, but not in the FaDu or SCC-25 cells.
|
10415749 |
1999 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these data indicate that activation of Jak/Vav/Rho GTPase pathway by CXCL12 is a key signaling event for MT1-MMP/MMP-2-dependent melanoma cell invasion.
|
16397238 |
2006 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
MMP-2 expression in uveal melanoma: differential activation status dictated by the cellular environment.
|
16379022 |
2005 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
More than 90% tumors expressed alpha6a, beta1, beta3 and beta6 (non-melanoma), and alpha5a, alpha6a and MMP2 (MM).
|
18251742 |
2008 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Induction of MDA-9/syntenin in melanoma was found to occur in a thrombin-independent signaling pathway and involves the PAR-1/c-Src/Rho GTPases Rac1 and Cdc42/c-Jun N-terminal kinase axis resulting in the activation of paxillin, NF-κB, and matrix metalloproteinase-2 (MMP-2).
|
25505176 |
2015 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We used a bioinformatics approach to assess the impact of amino acid (AA) substitutions on the sensitivity of CECMPs to proteases relevant to melanoma and on the binding affinities for HLA class I. CECMP peptides with AA substitutions overwhelmingly reflect increased sensitivity to proteases implicated in melanoma development (MME, CTSS, MMP2, CTSD, CTSL) in comparison to the wild-type peptide sequences.
|
29047110 |
2018 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study indicates that microcystin-LR can act as a NF-κB activator to promote MMP-2/-9 expression and melanoma cell invasion, which deserves more environmental health concerns.
|
22992115 |
2012 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, the prognostic value of MMP-2 and Ki-67 via immuno-staining in head and neck melanoma is investigated.
|
25313763 |
2015 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The melanoma cell lines showed different growth patterns in the brain, and these differences were associated with differences in expression of the angiogenic factors VEGF-A and IL-8 and the matrix metalloproteinases MMP-2 and MMP-9.
|
26667022 |
2015 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis.
|
16306050 |
2006 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Gelatinase A activity directly modulates melanoma cell adhesion and spreading.
|
7534227 |
1995 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Interestingly, male patients with a melanoma with overexpression of MMP-2 showed a 10-year disease-specific survival of only 41% compared with 77% in other male patients (P = .003).
|
18187184 |
2008 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Also, M21/OPN cells exhibit increased motility, which is markedly reduced upon treatment with inhibitors to alpha(v) and MMP-2.
|
16631740 |
2006 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Because MMP-2 activity is critical for melanoma progression, the MMP-2 peptide should be cross-presented by most progressing melanomas and represents a unique antigen for vaccine therapy of these tumors.
|
15998788 |
2005 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Matrix metalloproteinase-2 (MMP-2) has been detected in high levels and correlates with invasiveness in human melanoma.
|
18292932 |
2008 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
An inhibitor of stress-activated MAP-kinases reduces invasion and MMP-2 expression of malignant melanoma cells.
|
11918086 |
2002 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Importantly, knocking down CD147 attenuates MMP2 response to hypoxia in melanoma cell lines.
|
24090196 |
2014 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Our pilot study demonstrates that MMP2, MMP14, MMP9, and MaxND might be used as prognostic markers in patients with sinonasal and oral malignant melanoma.
|
18045645 |
2008 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Upregulation of MMP-2 activation by ED led to enhanced melanoma cells invasion through S-Gal occupancy.
|
15009703 |
2004 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Both melanoma cell invasion and MMP-2 activity increased and decreased with EIF5A2 overexpression and knockdown, respectively.
|
24178756 |
2014 |