|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Down-regulating Myoferlin inhibits the vasculogenic mimicry of melanoma via decreasing MMP-2 and inducing mesenchymal-to-epithelial transition.
|
29164766 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A novel matrix metalloproteinase-2 inhibitor triazolylmethyl aziridine reduces melanoma cell invasion, angiogenesis and targets ERK1/2 phosphorylation.
|
24246091 |
2014 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The myriad of biological effects exerted by elastokines on stromal and inflammatory cells led us to hypothesize that they might be main actors in elaborating a favorable cancerization field in melanoma; for instance these peptides could catalyze the vertical growth phase transition in melanoma through increased expression of gelatinase A and membrane-type 1 matrix metalloproteinase.
|
17498549 |
2007 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
When B16-BL6 melanoma cells or Lewis lung carcinoma cells were implanted intradermally, the tumor volumes at 3 weeks after implantation in the gelatinase A-deficient mice decreased by 39% for B16-BL6 melanoma and by 24% for Lewis lung carcinoma (P < 0.03 for each tumor).The number of lung colonies of i.v. injections fell by 54% for B16-BL6 melanoma and 77% for Lewis lung carcinoma (P < 0.014 and P < 0.0015, respectively).
|
9500469 |
1998 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Stromal cells as the major source for matrix metalloproteinase-2 in cutaneous melanoma.
|
16047212 |
2005 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This novel mechanism of action of wild-type p53 gene transfer may contribute to its antitumor effect by downregulating cell invasion and matrix metalloproteinase-2 secreted levels in mutated p53 human melanoma cell lines.
|
10844565 |
2000 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Plating cells onto type I or type IV collagen did not trigger pro-MMP-2 activation; on the contrary, conversion of pro-MMP-2 to its active form could be evidenced when melanoma cell lines were seeded in a three dimensional type I collagen lattice.
|
10763911 |
1999 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Activation of metalloproteinase (MMP) 2 expression greatly contributed to the BRG1 induced increase in melanoma invasiveness.
|
20969766 |
2010 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Therefore, CA can be characterized as a novel V-ATPase inhibitor for the treatment of melanoma that may inhibit invasion and metastasis by downregulating the expression of MMP-2 and -9.
|
29113270 |
2017 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Kinase activation led to increased MMP-2 and MT1-MMP expression and melanoma cell migration induced by hHK-1.
|
27458061 |
2016 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Additionally, alterations of SOCS-1 expression profoundly affected the expression of matrix metalloproteinase-2 (MMP-2), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) and the melanoma cell invasion and angiogenesis.
|
19047140 |
2008 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since AP-2 also regulates other genes that are involved in the progression of human melanoma such as c-KIT, E-cadherin, MMP-2, and p21(WAF-1), we propose that loss of AP-2 is a crucial event in the development of malignant melanoma.
|
9632718 |
1998 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The findings indicate that NCTD inhibits tumor growth and VM formation of melanoma both <i>in vitro</i> and <i>in vivo</i> by suppressing matrix metalloproteinase-2 expression.
|
28454306 |
2017 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show that METTL3 is upregulated in human melanoma and plays a role in invasion/migration through MMP2.
|
30762711 |
2019 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Only 4 of the breast/colorectal 'hill' type CAN genes (SMAD4, MYO18B, NAV3 and MMP2) were also mutated in melanoma and pancreatic carcinoma, while none was altered in glioblastoma.
|
19058223 |
2009 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Melanoma metastasis requires migration and invasion of the malignant tumour cells driven by proteolytic remodelling of the extracellular matrix (ECM) executed by matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9.
|
31020875 |
2019 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In parallel to CD44v3, MMP-2 expression (determined using immunohistochemistry) was significantly elevated (P<0.05) but only in the organ metastatic group of MM.
|
11764382 |
2001 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Hyaluronan fragments induce cytokine and metalloprotease upregulation in human melanoma cells in part by signalling via TLR4.
|
18031543 |
2008 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also demonstrate that: (1) among the major pro-angiogenic genes, FGF-2 was not increased before or after irradiation and vascular endothelial growth factor strongly inhibited after irradiation; (2) expression of two important metalloproteinases, matrix metalloproteinase 2 and 9, involved in melanoma metastasis were decreased before and after irradiation; (3) expression of their major inhibitor, tissue inhibitor of metalloproteinase, was mainly upregulated; and (4) that invasion of BRCA1 downregulated cells was modified.
|
15009718 |
2004 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
30%) attenuated the invasive activity of melanoma cells in a cell-based invasion assay and reduced MMP2 activity in the supernatant of melanoma cells.
|
17845054 |
2007 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We demonstrated that anterior lens capsule type IV collagen or specifically the synthetic peptide alpha3(IV) 185-203 inhibited both the migration of melanoma or fibrosarcoma cells as well as the activation of membrane-bound MMP-2 by decreasing the expressions of MT1-MMP and the beta3 integrin subunit.
|
10667602 |
2000 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The caspase-3-mediated promotion of melanoma cell motility may be because of the cleavage of matrix metalloproteinase-2.
|
23695439 |
2013 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Previously, we have shown that the progression of human melanoma to the metastatic phenotype is associated with loss of AP-2 expression and deregulation of target genes such as MUC18/MCAM, c-KIT, and MMP-2.
|
12789289 |
2003 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Immunolabeling of melanoma cells with antibodies specific for MMP-2 and MMP-9 led to the identification of two distinct populations of small cytoplasmatic vesicles containing MMP-2 or MMP-9, respectively.
|
15604254 |
2004 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because MMP-2 activity is critical for melanoma progression, the MMP-2 peptide should be cross-presented by most progressing melanomas and represents a unique antigen for vaccine therapy of these tumors.
|
15998788 |
2005 |