Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Matrix metallopeptidase 2 (MMP-2) and matrix metallopeptidase 9 (MMP-9) are involved in the breakdown of extracellular matrix in normal physiological processes as well as in disease processes, such as cancer metastasis.
|
31820313 |
2020 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
In ATAT for the group of patients with distant metastasis (M1) the superoxide generation rate, MMP-2, 9 activities are about 2 times higher (p < 0.05) than in the subgroup without distant metastases (M0).
|
31711773 |
2020 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Immunohistochemical expression was found for MMP-14 in all primary tumors as well as in all metastases and for MMP-2 expression in most of the samples.
|
30741846 |
2020 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
MMP2 is a downstream effector that influences the metastasis seen with uveal melanoma cells.
|
31661551 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Our results showed, reduction in MMP-2 (p=0.08), MMP-9 (p=0.03), CCL22 (p=0.003) and TGFβ1 (p=0.1) gene expression and Tregs frequency (p=0.01) which play a main role in the development of chronic inflammation, angiogenesis, tumorigenesis and metastasis.
|
30848576 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Thymoquinone inhibits metastasis of renal cell carcinoma cell 786-O-SI3 associating with downregulation of MMP-2 and u-PA and suppression of PI3K/Src signaling.
|
31217736 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Western blotting results revealed that knocking down ZEB2-AS1 could inhibit cell invasion and metastasis by suppressing the epithelial to mesenchymal transition (EMT) as well as the expressions of matrix metallopeptidase-2 (MMP-2) and MMP-9 in AGS cells.
|
31128021 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
MMP2 plays an important role in the metastasis of cancer cells.
|
30352219 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Therefore, our findings suggest that MIF may promote the invasion and metastasis of OSCC through the activation of MMP-2 and MMP-9 and prompt further investigation into the therapeutic value of MIF for OSCC treatment.
|
31219646 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
<b>Conclusion:</b><i>WFDC2</i> contributed to ovarian cancer metastasis and EMT as a positive regulator by activating AKT signaling pathway and inducing MMP-2 expression.
|
31118763 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
This induced the expression of metastasis‑associated genes, including C‑X‑C chemokine receptor 4, matrix metalloproteinase (MMP)1 and MMP2.
|
31485630 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
The experiments further demonstrated that SPG-56 inhibited the metastasis of breast cancer in MCF-7 and 4T1-bearing mice by altering the expression of MMP2, MMP9, VEGF, Occludin and Claudin.
|
30651572 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, the down-regulation of matrix metalloprotein 2 (MMP2) and MMP9 also reduce the rate of tumor metastasis.
|
31136911 |
2019 |
Neoplasm Metastasis
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
CT and TT genotypes at MMP2 C-1306T were associated with a significantly decreased risk of NPC metastasis.
|
31243109 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
T-MAN displays a high r<sub>1</sub> relaxivity (∼60.0 mM<sup>-1</sup> s<sup>-1</sup> per Gd<sup>3+</sup> at 1 T) and a large near-infrared (NIR) fluorescence turn-on ratio (∼185-fold) in response to MMP-2, allowing high-spatial-resolution magnetic resonance imaging (MRI) and low-background fluorescence imaging of gastric tumors as well as lymph node (LN) metastasis in living mice.
|
30688465 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Activation of pancreatic stellate cells may promote the expression of MMP2 and enhance the invasion and metastasis of pancreatic carcinoma.
|
30466735 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
MPPa-PDT downregulated the expression of MMP2 and MMP9, which are responsible for the initiation of metastasis.
|
31783821 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The effect of tomatidine on the inhibition of matrix metalloproteinase-2 (MMP-2) and MMP-9, gelatinases related to metastasis, was analyzed using gelatin zymography, western blot and immunofluorescence staining.
|
31545954 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Melanoma metastasis requires migration and invasion of the malignant tumour cells driven by proteolytic remodelling of the extracellular matrix (ECM) executed by matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9.
|
31020875 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
In summary, our study revealed a novel mechanism of the RBMS3/Twsit1/MMP2 axis in the regulation of invasion and metastasis of breast cancer, which may become a potential molecular marker for breast cancer treatment.
|
30819235 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
In an analysis of the miRNA target genes, we found that CDH2, KNG1, and MMP2 were correlated with CRC metastasis.
|
30807603 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are upregulated in most cancers and play crucial roles in modulating invasion and metastasis.
|
30074136 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The identification of the miR-146b/AUF1/ETS2/MMP2 mechanism for promoting bladder cancer invasion provides significant insights into understanding the nature of bladder cancer metastasis.
|
31071529 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Therefore, the DSTYK mutation may activate ERK1/2/MMP2/9 signaling to promote tumor cell metastasis in SFT/HPC.
|
31201369 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
IHC analysis revealed that a high expression of <i>UCA1</i> was accompanied by a high expression of metastasis-related proteins (MMP-2 and MMP-9), thereby validating the correlation of <i>UCA1</i> expression with metastasis.
|
30863094 |
2019 |