Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.370 GeneticVariation group LHGDN High-expressing MMP-3 genotype is associated with breast tumor progression 17922906 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.370 AlteredExpression group LHGDN Data suggest a role for MT1-MMP in early tumour progression, expression of MMP-1 during metastasis and focal expression pattern of MMP-3 and the expression profiles may provide markers for early breast cancer diagnoses and potential therapeutic targets. 17669621 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.370 Biomarker group CTD_human ERE-independent ERalpha target genes differentially expressed in human breast tumors. 16298037 2006
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.370 Biomarker group BEFREE MMP-1 (interstitial collagenase) has been associated with MDA-MB-231 invasion in vitro, while MMP-3 (stromelysin-1) has been localised around invasive cells of breast tumours in vivo. 16430785 2006
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.370 AlteredExpression group LHGDN The expression of MMP3 is consistently significantly higher in neoplastic brain tissue compared to normal brain tissue, and may be involved in the process of metastasis of breast cancer to the brain. 16158251 2005
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.370 GeneticVariation group LHGDN MMP3 5A/6A promoter polymorphism does not appear to influence breast cancer susceptibility but may be linked to a higher risk for metastasizing among breast cancer patients 15161710 2004
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.370 GeneticVariation group LHGDN A single nucleotide polymorphism in MMP-3 promoter is associated with invasive behaviour in breast cancer 12473595 2003
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.370 Biomarker group BEFREE The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter. 10713697 2000