MMP8, matrix metallopeptidase 8, 4317

N. diseases: 213; N. variants: 10
Disease: Mammary Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.040 Biomarker group BEFREE We demonstrated that a local ECM degradation and remodeling in solid tumors by means of collagenase-2 could enhance tumor penetration of nanomedicines and the in situ sustained release of the drug payload throughout 3-D tumor spheroids up to the core (parenchyma), thus enabling a synergistic and efficient anticancer effect toward highly invasive breast tumors. 30458257 2019
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.040 AlteredExpression group BEFREE Analysis of MMP-8 in breast cancer patients revealed that the expression of this metalloproteinase by breast tumors correlates with a lower incidence of lymph node metastasis and confers good prognosis to these patients. 18413742 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.040 Biomarker group LHGDN Plasma MMP1 and MMP8 expression in breast cancer: protective role of MMP8 against lymph node metastasis. 18366705 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.040 GeneticVariation group LHGDN Association of matrix metalloproteinase-8 gene variation with breast cancer prognosis. 17974962 2007