Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Matrix metalloproteinase-9 (MMP-9), a key determinant of extracellular matrix degradation, might cause cerebral damage after stroke and be involved in the development of depressive symptoms.
|
31564697 |
2019 |
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
MMP-9 polymorphisms were independently associated with severe stroke and higher risk of END, and prestroke antithrombotic treatment was associated with less severe stroke and lower risk of END in patients with AF.
|
31012282 |
2019 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
The present study is the first to demonstrate that cold exposure exacerbates imbalance between MMP-9 and TIMP-1 by activating the RAS, which may be critical in the initiation of stroke during chronic hypertension.
|
31200003 |
2019 |
Cerebrovascular accident
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Higher plasma MMP-9 levels are significantly correlated with cold-induced stroke in hypertensive rats treated with intermittent cold stress.
|
31349015 |
2019 |
Cerebrovascular accident
|
0.300 |
AlteredExpression
|
group |
BEFREE |
The infarct volume, as well as serum levels of matrix metalloproteinase-9 (MMP-9) and interleukin-10 (IL-10), were measured one week after stroke.
|
31807255 |
2019 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Impact statement Matrix metalloproteinase-9 ( MMP-9) is a possible candidate gene for some diseases, including metabolic syndrome, stroke, coronary artery disease (CAD).
|
29763368 |
2018 |
Cerebrovascular accident
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Compared with this, 11 genetic factors such as MMP9 were found to be differentially expressed in both acute and recovery phases of stroke showing their indicating roles in stroke.
|
30158363 |
2018 |
Cerebrovascular accident
|
0.300 |
AlteredExpression
|
group |
BEFREE |
S1RA-treated mice showed faster behavioural recovery from stroke; this finding complements the significant decreases in matrix metalloproteinase-9 (MMP-9) expression and reactive astrogliosis surrounding the infarcted cortex.
|
28779350 |
2018 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Using our polymeric system to deliver VEGF-A and MMP-9, we improved recovery after stroke to an equivalent degree as observed with traditional stem cell treatment in a rodent model.
|
29909038 |
2018 |
Cerebrovascular accident
|
0.300 |
AlteredExpression
|
group |
BEFREE |
There was a robust increase in MMP-9 expression (immunofluorescence) in the ischemic vs. the non-ischemic hemisphere of MMP-9<sup>+/+</sup> but not MMP-9<sup>-/-</sup> mice, 24 h after stroke.
|
29294343 |
2018 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Plasma MMP-9 concentrations were determined using enzyme-linked immunosorbent assay, and sHT was diagnosed based on brain computed tomography or magnetic resonance performed 3-14 d after stroke onset.
|
30287248 |
2018 |
Cerebrovascular accident
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Compared to PBS treatment, APX3330 treatment significantly decreases plasminogen activator inhibitor type-1 (PAI-1), monocyte chemotactic protein-1 and matrix metalloproteinase 9 (MMP9) and receptor for advanced glycation endproducts expression in the ischemic brain of T1DM stroke rats.
|
29896433 |
2018 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Diagnostic accuracy of a single measurement of the 3 biomarkers for stroke using AUC (95% confidence interval) plots were as follows: .84 (.77-0.91), P < .0001, for GFAP; .85 (.79-0.92), P < .0001, for copeptin; and .65 (.56-0.73), P = .0003, for MMP-9.
|
29074065 |
2018 |
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Subgroup analysis by the type of stroke showed that MMP-9 gene rs3918242 polymorphism increased the risk of ischemic stroke.
|
30132967 |
2018 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
An insignificant relationship between MMP-9 and clinical events within 1 year (death, AMI, or stroke) (n = 15) was observed, probably due to the lack of statistical power.
|
29141241 |
2018 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
MMP-9 is involved in the pathological process of hemorrhagic stroke through a variety of mechanisms and is closely related to prognosis after cerebral hemorrhagic stroke.
|
28460607 |
2017 |
Cerebrovascular accident
|
0.300 |
AlteredExpression
|
group |
BEFREE |
The serum level of MMP-9 at stroke onset was independently positively correlated with stroke outcome.
|
28063771 |
2017 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Hypoxia Response Element-Regulated MMP-9 Promotes Neurological Recovery via Glial Scar Degradation and Angiogenesis in Delayed Stroke.
|
28396199 |
2017 |
Cerebrovascular accident
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Combination therapy also decreased BBB leakage (P<0.001), MMP-9 level or edema (P<0.05) and improved neurological functions at 24 and 48h after stroke.
|
28710023 |
2017 |
Cerebrovascular accident
|
0.300 |
AlteredExpression
|
group |
BEFREE |
In addition, PKal inhibition reduced matrix metalloproteinase-9 activity in brain following stroke and tPA therapy.
|
28130211 |
2017 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Matrix metalloproteinases (MMPs), specifically MMP-2, MMP-7, and MMP-9, have been discovered to be linked to many forms of vascular diseases such as stroke, and their detection is crucial to facilitate clinical diagnosis.
|
28245103 |
2017 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Therefore, our findings demonstrate that miconazole protects blood vessels from hemorrhages by downregulating the pERK-MMP9 axis from zebrafish to mammals and shed light on the potential of phenotype-based screens in zebrafish for the discovery of new drug candidates and chemical probes for hemorrhagic stroke.
|
28153846 |
2017 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Furthermore, regulatory T cell-afforded protection in the tPA-treated stroke model is mediated by two inhibitory mechanisms involving CCL2 and MMP9.
|
28535201 |
2017 |
Cerebrovascular accident
|
0.300 |
AlteredExpression
|
group |
BEFREE |
These actions mitigated neuronal apoptosis in the stroke penumbra, and decreased matrix metallopeptidase-9 (MMP-9) expression.
|
28963051 |
2017 |
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
In conclusion, our findings suggest that MMP-9 C(-1562)T polymorphism is significantly associated with risk of stroke in patients with and without T2DM.
|
26330106 |
2015 |