MMP12, matrix metallopeptidase 12, 4321

N. diseases: 216; N. variants: 12
Disease: Myocardial Infarction ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.040 Biomarker disease BEFREE Importantly, the survival rate and cardiac function after MI were significantly impaired in MMP-12-deficient (mmp12<sup>-/-</sup>) mice compared with those in wild-type mice. 31009606 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.040 Biomarker disease BEFREE MMP-12 is related to several diseases such as emphysema, myocardial infarction and liver fibrosis. 30880028 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.040 Biomarker disease BEFREE We review here the evidence that MMP-12 may serve as a novel RPF with potential therapeutic efficacy in the setting of MI. 30394317 2018
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.040 AlteredExpression disease BEFREE In a population cohort, we found that individuals homozygous for the MMP12 low expression allele had higher plasma fibrinogen levels (2.95 mg/mL compared with 2.61 mg/mL in other individuals, p=0.029) and increased risk of advanced atherosclerosis [odds ratio 6.3 (95% CI 1.9-20.8), p=0.003] and myocardial infarction [hazard ratio 5.6 (95% CI 1.7-18.3), p=0.005]. 22119538 2012