MMP12, matrix metallopeptidase 12, 4321

N. diseases: 216; N. variants: 12
Disease: Systemic Scleroderma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.050 Biomarker disease BEFREE Matrix metalloproteinase-12-dependent uPAR cleavage was implicated in the induction of EndoMT by SSc sera. 28062404 2017
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.050 Biomarker disease BEFREE Loss of function of MMP12 and PTX3 in SSc MVECs restores the ability of the cells to produce capillaries in vitro and induces vascularization in vivo on a Matrigel sponge. 20506099 2010
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.050 GeneticVariation disease BEFREE The MMP-12 rs2276109 gene polymorphism may contribute to susceptibility to SSc, and in particular to dcSSc and pulmonary fibrosis. 20595276 2010
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.050 GeneticVariation disease BEFREE We have previously shown that endothelial cell matrix metalloprotease 12 (MMP12) and pentraxin 3 (PTX3) overproduction is the main alteration accounting for reduced proneness to angiogenesis in systemic sclerosis (SSc). 19794969 2009
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.050 Biomarker disease BEFREE In systemic sclerosis (SSc) microvascular endothelial cells (MVECs), angiogenesis is blocked by matrix metalloproteinase 12-dependent cleavage of domain 1 of the urokinase-type plasminogen activator receptor (uPAR). 17133606 2006