MMP14, matrix metallopeptidase 14, 4323

N. diseases: 340; N. variants: 7
Disease: bone destruction ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0238790
Disease: bone destruction
bone destruction 		0.020 Biomarker disease BEFREE These data provide the first genetic evidence that cells other than osteoclasts can cause focal bone destruction in inflammatory bone disease and suggest that MMP14 is a key mediator conferring pathological bone-resorbing capacity on c-Fos-deficient Sh3bp2<sup>KI/KI</sup> macrophages. 28914985 2018
CUI: C0238790
Disease: bone destruction
bone destruction 		0.020 Biomarker disease BEFREE MMP activity was detected in CK(-/-) osteoclasts, and MMP-14 was localized by immunohistochemistry in inflammatory bone erosions in hTNF-transgenic CK(-/-) mice, suggesting MMPs as potential contributors to bone destruction. 18240253 2008