Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Compared with that in the DSS group, FMT ameliorated the severity of inflammation due to ulcerative colitis in mice, which was accompanied by a significantly decreased MPO activity, reduced levels of TNF-α and IL-1β, and an increased level of IL-10 in colon tissue (all P<0.05).
|
30906449 |
2019 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The results indicated that treatment with EVO ameliorated DSS-induced UC mice body weight loss, disease activity index (DAI), colon length shortening, colonic pathological damage, and myeloperoxidase (MPO) activity.
|
30554117 |
2019 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
It is found that the anti-UC activities are mainly focused on targeting inflammation or oxidative stress, which is associated with increasing the levels of anti-inflammatory cytokine (IL-4, IL-10, SOD), suppressing the levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8, IL-23, NF-κB, NO), reducing the activity of MPO, MDA, IFN-γ, and iNOS.
|
30797423 |
2019 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Meanwhile, MAP induced high specific antibody titers in vivo, reduced the DAI score, serum MPO activity, colorectal lymph node colony count, ultrastructural injuries, colon tissue histological index score and MPO activity in UC mice, while increasing the expression levels of occludin, claudin1 and ZO1 in colon tissues.
|
31524230 |
2019 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The results showed that treatment with Lico A significantly reduced the colon length, histological damage scores, and colonic myeloperoxidase (MPO) activity in a dose-dependent manner as compared to the UC control group.
|
29710547 |
2018 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Biochemical analysis was carried out for asserting the levels of tissue myeloperoxidase (MPO) accumulation, SOD concentrations, reduced GSH and lipid peroxidation in UC induced and treated animals.
|
29530609 |
2018 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Microscopic images of tissue sections of colon extracted from UC model mice demonstrated that HSA NPs and MPO were both localized in the colon, and this specific interaction between HSA NPs and MPO would be involved the in the therapeutic effect in vivo.
|
29407223 |
2018 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
After orally administrating a GCZX-pill to UC rats for 14 days, the results of the inflammation evaluation, such as disease activity index (DAI), macroscopic score (MS), myeloperoxidase (MPO) activity, and other methods, suggested that the GCZX-pill showed remarkable anti-inflammatory results in UC rats.
|
28845184 |
2017 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
MSE decreased colonic secretions of pro-inflammatory keratinocyte-derived cytokine (KC), tumor necrosis factor (TNF)-α, nitric oxide (NO), and myeloperoxidase (MPO) in acute and chronic UC; reduced fecal lipocalin-2 in acute UC; downregulated gene expression of pro-inflammatory interleukin (IL)-1, IL-6, TNF-α, and inducible nitric oxide synthase (iNOS) in acute UC; upregulated expression of claudin-1 and ZO-1 in acute and chronic UC; and upregulated GSTP1, an Nrf2-mediated phase II detoxifying enzyme, in chronic UC.
|
28922365 |
2017 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Disease activity index (DAI), histological damage score (HDS) and myeloperoxidase (MPO) activity were used to evaluate the severity of UC.
|
28781623 |
2017 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Targeting sphingosine kinase 1 (SphK1) and apoptosis by colon-specific delivery formula of resveratrol in treatment of experimental ulcerative colitis in rats.
|
24055189 |
2013 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The epigenetic/genetic associations related to elevated MPO staining in UC-CRC may offer new methods for risk stratification and adjunctive screening tools.
|
21425209 |
2012 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Suppression of TNBS-induced colitis in rats by 4-methylesculetin, a natural coumarin: comparison with prednisolone and sulphasalazine.
|
22119283 |
2012 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Inflammatory cells' infiltration and MPO activity increased significantly in the untreated UC, but was significantly lower in the treated UC groups 3 and 4 (P < 0.05).
|
21221801 |
2011 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Intestinal anti-inflammatory activity of esculetin and 4-methylesculetin in the trinitrobenzenesulphonic acid model of rat colitis.
|
20380826 |
2010 |