|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we propose that a molecularly distinct subtype of acute leukaemia with shared myeloid and T cell lymphoblastic features, which we term acute myeloid/T-lymphoblastic leukaemia (AMTL), is divided across 3 diagnostic categories owing to variable expression of markers deemed to be defining of myeloid and T-lymphoid lineages, such as myeloperoxidase and CD3.
|
29441563 |
2018 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Besides myeloperoxidase (MPO), which was used as the gold standard in differentiating AML from other type of ALs, the most specific markers for AML in our study were CD14 and CD64 (99.5 and 95.6%).
|
28625325 |
2017 |
|
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
One of the patients also had myeloperoxidase expression and was diagnosed as mixed phenotype B/myeloid acute leukemia.
|
27392123 |
2016 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cytochemistry showed myeloperoxidase-positive cells in all T/myeloid acute leukemias (3%-50%).
|
22261446 |
2012 |
|
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MPO G-463A variant may possess a protective genetic marker against acute leukemia in the Chinese Han population.
|
17479404 |
2007 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Multilineage involvement of light microscopic myeloperoxidase-negative acute leukemia.
|
16298822 |
2005 |
|
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We established three sister cell lines, NALM-30, NALM-31 and NALM-32, with biphenotypic features carrying myeloperoxidase mRNA and protein with complex Philadelphia (Ph) chromosome, t(9;22;10)(q34;q11;q22), from a patient with Ph-positive acute leukemia in relapse.
|
10363160 |
1998 |
|
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The FAB classification of acute leukaemias is based on the light microscopic detection of myeloperoxidase (MPO) activity in blast cells.
|
9217186 |
1997 |
|
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Use of myeloperoxidase mRNA as a marker for myeloid lineage in acute leukemias.
|
9140287 |
1996 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A novel human leukemia cell line (Kasumi-3) was established from the blast cells of a 57-year-old man suffering from myeloperoxidase-negative acute leukemia.
|
8613429 |
1996 |
|
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Conversely, acute leukemias that express only myeloid antigens are also considered to be acute myelogenous leukemia (AML), even in the absence of MPO.
|
7493141 |
1995 |
|
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MPO enzyme activity as determined by light microscopic cytochemistry has long been an important marker used in the diagnosis of acute leukemias and other hematopoietic disorders.
|
7866270 |
1994 |
|
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A new procedure for cell lineage determination in acute leukemias. Myeloperoxidase mRNA detection.
|
8269279 |
1993 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have studied immunological features of 200 cases of acute leukemia (109 acute myelogenous leukemia, AML, and 91 acute lymphoblastic leukemia, ALL, according to FAB criteria), including 17 (8.5%) classified as biphenotypic by a scoring system based on the number and specificity of unexpected lineage antigens and which gives more weight to cytoplasmic markers such as myeloperoxidase, CD3, and CD22, and less to other membrane markers.
|
8501986 |
1993 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The enzyme myeloperoxidase (MPO), an important constituent of granulocytes, is used clinically in the diagnosis and classification of acute leukemia.
|
8118606 |
1993 |
|
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To determine if mutations in this putatively regulatory region of the MPO gene might be responsible for some of the differences in level of MPO expression among different cases or classes of acute leukemia, we compared the nucleotide sequence of this part of the gene from 16 patients with acute leukemia, with DNA from normal human bone marrow cells and selected other neoplasms and cell lines.
|
8396697 |
1993 |
|
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We conclude by showing that ISH can detect MPO mRNA in myeloblasts of patients with acute leukemia and can be a potentially useful technique in the study of myeloid differentiation in acute leukemias.
|
2173803 |
1990 |
|
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that MPO gene expression may serve as an additional marker for subclassification of acute leukemias and may be used to identify leukemic cells arrested at an early stage of the myeloid differentiation pathway.
|
2553160 |
1989 |