Disease: HIV Infections ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019693
Disease: HIV Infections
HIV Infections 		0.010 Biomarker group BEFREE We investigated early innate defense against human immunodeficiency virus (HIV) infection and viral evasion by utilizing human CD4<sup>+</sup> T cell cultures <i>in vitro</i> and a simian immunodeficiency virus (SIV) model of AIDS <i>in vivo</i> Our data showed that early host innate defense against the viral infection involves GCN2-ATF4 signaling-mediated suppression of global protein synthesis, which is exploited by the virus for supporting its own replication during early viral infection and dissemination in the gut mucosa. 28465428 2017