Hereditary Nonpolyposis Colorectal Cancer
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Lynch Syndrome (LS) is associated with germline mutations in one of the mismatch repair (MMR) genes, including MutL homolog 1 (MLH1), MutS homolog 2 (MSH2), MSH6, PMS1 homolog 2, mismatch repair system component (PMS2), MLH3 and MSH3.
|
29568967 |
2018 |
Hereditary Nonpolyposis Colorectal Cancer
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
So far, the role of germline MSH3 variants remains unclear, as to our knowledge heterozygous truncating variants are not regarded causative for LS, but were detected in patients with CRC, and recently biallelic MSH3 defects have been identified in two patients with adenomatous polyposis.
|
28528517 |
2017 |
Hereditary Nonpolyposis Colorectal Cancer
|
0.390 |
Biomarker
|
disease |
CLINGEN |
Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis.
|
27476653 |
2016 |
Hereditary Nonpolyposis Colorectal Cancer
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Additionally, we observed differences in MSH3 and TGFBR2 mutational frequency between Lynch syndrome and sporadic MSI CRC regarding tumour location.
|
26247575 |
2015 |
Hereditary Nonpolyposis Colorectal Cancer
|
0.390 |
Biomarker
|
disease |
CLINGEN |
Tissue-specific mismatch repair protein expression: MSH3 is higher than MSH6 in multiple mouse tissues.
|
23228367 |
2013 |
Hereditary Nonpolyposis Colorectal Cancer
|
0.390 |
Biomarker
|
disease |
CLINGEN |
To determine a possible role of MSH3 as predisposing to CRC in Lynch syndrome, we screened MSH3 for germ-line mutations in 79 unrelated Lynch patients who were negative for pathogenetic mutations in MLH1, MSH2 and MSH6.
|
21128252 |
2011 |
Hereditary Nonpolyposis Colorectal Cancer
|
0.390 |
Biomarker
|
disease |
BEFREE |
To determine a possible role of MSH3 as predisposing to CRC in Lynch syndrome, we screened MSH3 for germ-line mutations in 79 unrelated Lynch patients who were negative for pathogenetic mutations in MLH1, MSH2 and MSH6.
|
21128252 |
2011 |
Hereditary Nonpolyposis Colorectal Cancer
|
0.390 |
Biomarker
|
disease |
CLINGEN |
The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression.
|
10706084 |
2000 |
Hereditary Nonpolyposis Colorectal Cancer
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Two germline mutations in the hMSH6 region have been reported in hereditary nonpolyposis colorectal cancer (HNPCC); however, no germline mutations in the hMSH3 gene have been reported yet.
|
9929971 |
1999 |
Hereditary Nonpolyposis Colorectal Cancer
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
These data support the notion that these HNPCC-associated mutations may affect some other function of the heterodimeric complexes than simply the static interaction of hMSH2 with hMSH3 or hMSH2 with hMSH6.
|
9774676 |
1998 |
Hereditary Nonpolyposis Colorectal Cancer
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
To clarify the tumorigenetic role of hMSH3, we screened for somatic mutations at the hMSH3 (A)8 repeat in 29 tumors from 23 hereditary nonpolyposis colorectal cancer patients.
|
9240418 |
1997 |
Hereditary Nonpolyposis Colorectal Cancer
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
The redundant functions of MSH3 and MSH6 explain the greater prevalence of hmsh2 mutations in HNPCC families.
|
9024626 |
1997 |
Hereditary Nonpolyposis Colorectal Cancer
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
A germ-line mutation of hMSH6 (also called GTBP) was found in a hereditary nonpolyposis colorectal cancer (HNPCC)-like patient in whom germ-line mutations of hMSH2, hMSH3, or hMLH1 had not been detected.
|
9307272 |
1997 |
Hereditary Nonpolyposis Colorectal Cancer
|
0.390 |
Biomarker
|
disease |
CLINGEN |
hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6.
|
8942985 |
1996 |
Hereditary Nonpolyposis Colorectal Cancer
|
0.390 |
Biomarker
|
disease |
CLINGEN |
hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA.
|
8805365 |
1996 |