Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide significant associations were observed with 84 variants all located at the known PrCa risk regions at 8q24 (128.484-128.548) and 10q11.22 (MSMB gene).
|
31226226 |
2020 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study of prostate cancer in Latinos.
|
31226226 |
2020 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Plasma MSP concentrations were inversely associated with prostate cancer risk after adjusting for total prostate-specific antigen concentration [odds ratio (OR) highest versus lowest fourth of MSP = 0.65, 95% confidence interval (CI) 0.51-0.84, Ptrend = 0.001].
|
31089709 |
2019 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A total of 31 proteins were associated with prostate cancer risk including proteins encoded by <i>GSTP1</i>, whose methylation level was shown previously to be associated with prostate cancer risk, and <i>MSMB, SPINT2, IGF2R</i>, and <i>CTSS</i>, which were previously implicated as potential target genes of prostate cancer risk variants identified in genome-wide association studies.
|
31337649 |
2019 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our data revealed that the T allele of MSMB rs10993994 polymorphism was significantly associated with PCa in all subjects (allele contrast: OR=1.24, 95% CI=1.19-1.29, p<0.001).
|
31773691 |
2019 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The results of our study suggest that combined PSP94/PTEN analysis can be potentially used in the clinical prognosis of prostate cancer.
|
31516752 |
2019 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Hitherto, these conditions have been not studied in Mexico yet, neither if sexually transmitted infections could modify the MSMB and PC association.
|
30774776 |
2019 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Additionally, 6 pathways were identified based on identified variants and genes, including estrogen signaling pathway, signaling by MST1, IL-15 production, MSP-RON signaling pathway, and IL-12 signaling and production in macrophages, which are known to be associated with prostate cancer.
|
31748686 |
2019 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population.
|
31562322 |
2019 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
MSMB levels are also reduced in the circulation and MSMB is therefore used as a serum biomarker for prostate cancer.
|
29250809 |
2018 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
We also review the diagnostic assays that are developed for PSP94 for use in the diagnosis of PCa and use of such tests in the differential diagnosis of PCa from benign prostatic hyperplasia (BPH).
|
28930560 |
2018 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
|
29892016 |
2018 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our data also demonstrated that HGF/c-Met, but not the MSP-RON signaling pathway may be the dominant mechanism for PCa EMT.
|
28440432 |
2017 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
We assessed the performance of a 4-kallikrein panel with and without microseminoprotein-β to predict high grade (Gleason 7+/Gleason Grade Group 2+) prostate cancer on biopsy in a multiethnic cohort from PLCO (Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial).
|
27810449 |
2017 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis indicates that MSMB gene rs10993994 polymorphism increases the risk of PC.
|
28212531 |
2017 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Across 66 meta-analyses, a total of 20 genetic variants involving 584,100 subjects in 19 different genes (KLK3, IGFBP3, ESR1, SOD2, CAT, CYP1B1, VDR, RFX6, HNF1B, SRD5A2, FGFR4, LEP, HOXB13, FAS, FOXP4, SLC22A3, LMTK2, EHBP1 and MSMB) exhibited significant association with prostate cancer.
|
26967244 |
2016 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this report, individual domains of prostate cancer related biomarkers; MSMB and PSA were overexpressed in bacterial system and purified in their folded forms using affinity chromatography.
|
27038170 |
2016 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our objective was to determine the gene expression pattern of the SFRP family in prostatic cell lines and fresh frozen tissues from normal prostates (NP), benign prostatic hyperplasia (BPH) and prostate cancer (PCa), by qRT-PCR, and their DNAme status by MSP and bisulfite sequencing.
|
27570179 |
2016 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Two susceptibility loci identified for prostate cancer aggressiveness.
|
25939597 |
2015 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer.
|
26443449 |
2015 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The methylation of GSTP1 and RASSF1A was investigated by using the MSP in 50 prostate cancer and 17 benign prostate hyperplasia specimens.
|
25577235 |
2015 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.
|
26034056 |
2015 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
A peak at m/z 10,760 was identified as β-microseminoprotein (β-MSMB) and found to be statistically lower in urine from PCa participants using the peak's average areas.
|
24115268 |
2014 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association scan for variants associated with early-onset prostate cancer.
|
24740154 |
2014 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Another novel mechanism, which we propose in this review article, is that PSP94 may protect against prostate cancer by preventing or limiting an intracellular fungal infection in the prostate.
|
24464504 |
2014 |