MSR1, macrophage scavenger receptor 1, 4481

N. diseases: 108; N. variants: 12
Disease: Prostate cancer, familial ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.580 Biomarker disease GENOMICS_ENGLAND Germline genetic profiling in prostate cancer: latest developments and potential clinical applications. 28031937 2016
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.580 SusceptibilityMutation disease ORPHANET Many polymorphisms in genes, such as ELAC2 (locus HPC2), RNase L (locus hereditary prostate cancer 1 gene [HPC1]), and MSR1 have been recognized as important genetic factors that confer an increased risk of developing prostate cancer in many populations. 23141781 2013
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.580 GeneticVariation disease BEFREE Many polymorphisms in genes, such as ELAC2 (locus HPC2), RNase L (locus hereditary prostate cancer 1 gene [HPC1]), and MSR1 have been recognized as important genetic factors that confer an increased risk of developing prostate cancer in many populations. 23141781 2013
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.580 Biomarker disease BEFREE The MSR1 gene at 8p22 has been suggested as a candidate gene for hereditary prostate cancer because germline variants have been found to be associated with the disease. 16287155 2006
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.580 GeneticVariation disease BEFREE These include the ELAC2 (HPC2), MSR1, and RNASEL (HPC1) genes that have germline mutations in familial prostate cancer; AR, ATBF1, EPHB2 (ERK), KLF6, mitochondria DNA, p53, PTEN, and RAS that have somatic mutations in sporadic prostate cancer; AR, BRCA1, BRCA2, CHEK2 (RAD53), CYP17, CYP1B1, CYP3A4, GSTM1, GSTP1, GSTT1, PON1, SRD5A2, and VDR that have germline genetic variants associated with either hereditary and/or sporadic prostate cancer; and ANXA7 (ANX7), KLF5, NKX3-1 (NKX3.1), CDKN1B (p27), and MYC that have genomic copy number changes affecting gene function. 16267836 2006
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.580 Biomarker disease BEFREE Genetic studies have identified RNASEL, encoding an interferon inducible ribonuclease, and MSR1, encoding subunits of the macrophage scavenger receptor, as candidate inherited susceptibility genes for familial prostate cancer. 15535435 2004
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.580 Biomarker disease BEFREE The macrophage scavenger receptor 1 (MSR1) gene on chromosome 8p22 was recently reported as a candidate gene for hereditary prostate cancer (HPC). 15042613 2004
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.580 GeneticVariation disease BEFREE To confirm these findings, we screened MSR1 for germline mutations among individuals with familial prostate cancer and tested gene variants for associations in both sporadic and familial prostate cancer. 12958598 2003
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.580 GeneticVariation disease BEFREE Rare germline mutations of macrophage scavenger receptor 1 (MSR1) gene were reported to be associated with prostate cancer risk in families with hereditary prostate cancer (HPC) and in patients with non-HPC (Xu et al.2002). 12471593 2003
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.580 GeneticVariation disease BEFREE The MSR1 gene maps to 8p22-23, a novel susceptibility locus for hereditary prostate cancer (HPC). 14614006 2003
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.580 SusceptibilityMutation disease ORPHANET Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. 12244320 2002