|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, some lncRNAs, such as MEG3, MT1JP, and H19, play a tumor suppressive role.
|
31202519 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These data suggested that lncRNA MT1JP acts a tumor suppressor gene in bladder cancer progression, considering MT1JP as a new therapeutic target in bladder cancer.
|
30786017 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our rescue experiments showed that the tumor suppressive and cisplatin-sensitizing functions of MT1JP were mediated by negative regulation of miR-24-3p.
|
30787983 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MT1JP has recently been reported to be differentially expressed and act as a tumor suppressor in different tumors, with its mechanisms not fully understood in GC.
|
29742512 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The melatonin-MT1 receptor axis modulates tumor growth in PTEN-mutated gliomas.
|
29408377 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We demonstrated that MT1JP was a tumor suppressor by negatively modulating the activity of the Wnt/β-catenin signaling pathway in the development of retinoblastoma and might function as a prognostic biomarker and therapeutic target.
|
30024609 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study we show that mammary tumors from MTB-IGFIR transgenic mice and cell lines derived from these tumors represent a model of human claudin-low breast cancer and murine claudin-low mammary tumors and cell lines express only very low levels of all five members of the miR-200 family.
|
28423599 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the present study, we report a lncRNA named MT1JP which acts as a tumor suppressor through a posttranscriptional mechanism.
|
26909858 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MTB-IGFIR mice fed a soy-based diet displayed increased tumor incidence and accelerated tumor onset compared to MTB-IGFIR mice fed a casein diet.
|
25655427 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The lymphoid component accompanying the tumor was always negative for MT1 receptor.
|
23073719 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, this approach was utilized to classify the mammary tumors that develop in MTB-IGFIR transgenic mice.
|
22020329 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Previously, we have shown that downregulation of IGF-IR transgene in mammary tumors in MTB-IGFIR transengic mice results in tumor regression in a majority of the mice and most of these mice do not develop recurrent mammary tumors.
|
20543862 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the current studies, we have examined the expression of the MT1 receptor in breast cancer cell lines and primary human breast tumors and correlated MT1 receptor expression with the deletion, rearrangement and amplification of the MT1 gene and established markers of breast cancer such as tumor size, stage, estrogen receptor alpha (ERalpha) and progesterone receptor (PR) expression.
|
18979234 |
2009 |