|
Breast Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
The aim of this cross-sectional study was to elucidate the expression pattern of MT1 receptor in relation to estrogen, progesterone, and HER2 receptors in breast carcinoma.
|
31290783 |
2019 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
MT-1 protein in women of reproductive age was significantly higher in breast cancer than in fibroadenoma in this study.
|
31092851 |
2019 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
We synthesized and screened five drug conjugates (C2, C4, C5, C9, and C15 linked) for their effects on BC cell (MCF-7, tamoxifen-resistant MCF-7, mouse mammary carcinoma, MDA-MB-231, and BT-549) viability, migration, and binding affinity to melatonin receptor 1 (MT1R) and estrogen receptor 1 (ESR1).
|
31221824 |
2019 |
|
Breast Carcinoma
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
There was no evidence that associations differed according to MT1R status of the tumor (e.g., <i>P</i><sub>heterogeneity for overall breast cancer</sub> = 0.88).<b>Conclusions:</b> Higher urinary melatonin levels were associated with reduced breast cancer risk in this cohort of postmenopausal women, and the association was not modified by MT1R subtype.<b>Impact:</b> Urinary melatonin levels appear to predict the risk of breast cancer in postmenopausal women.
|
28151704 |
2017 |
|
Breast Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
The lowest MT1 protein expression level was noted in the TN breast cancer cell line MDA-MB-231 compared with ER+ cell lines MCF-7 and SK-BR-3.
|
23330677 |
2013 |
|
Breast Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Melatonin, via activation of its MT1 receptor, suppresses the development and growth of breast cancer by regulation of growth factors, regulation of gene expression, regulation of clock genes, inhibition of tumor cell invasion and metastasis, and even regulation of mammary gland development.
|
20050373 |
2009 |
|
Breast Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
In the current studies, we have examined the expression of the MT1 receptor in breast cancer cell lines and primary human breast tumors and correlated MT1 receptor expression with the deletion, rearrangement and amplification of the MT1 gene and established markers of breast cancer such as tumor size, stage, estrogen receptor alpha (ERalpha) and progesterone receptor (PR) expression.
|
18979234 |
2009 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
In MCF-7 breast cancer cells transfected with a vector carrying the MT1 gene (MCF-7Mel1a) binding of CREB-protein to the cAMP-responsive element of the breast cancer suppressing gene BRCA-1 was more strongly reduced by treatment with melatonin than in the parental cells.
|
19522736 |
2009 |
|
Breast Carcinoma
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The gene and phenotype frequencies of 5-MT I and 5-MT II were not significantly different in genomic DNA samples from a series of non-Hodgkin's lymphomas and breast cancer cases compared with DNA from normal subjects.
|
9694254 |
1998 |