Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Non-Latin European descent could be a requirement for association of NTDs and MTHFR variant 677C > T: a meta-analysis.
|
17618486 |
2007 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In the father group, MTHFR C677T was a risk factor for NTDs.
|
31238314 |
2019 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Thrombophilia-associated gene mutations in women with pregnancies complicated by fetal neural tube defects.
|
18068170 |
2008 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Omphalocele cases were significantly more likely to carry the T allele of MTHFR 677C-->T, a known risk factor for NTDs (odds ratio 3.50, 95% confidence interval 1.07-11.47, P=0.035).
|
15937947 |
2005 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Correlation of polymorphism of MTHFRs and RFC-1 genes with neural tube defects in China.
|
18022874 |
2008 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Low folate intake as well as alterations in folate metabolism as a result of polymorphisms in the enzyme methylenetetrahydrofolate reductase (MTHFR) have been associated with an increased incidence of neural tube defects, vascular disease, and some cancers.
|
11274424 |
2001 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A similar allele frequency in groups M and NTD does not support a causal relationship between NTD and parental MTHFR C677T genotypes.
|
10998450 |
2000 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
When broken down into the various 677 ct MTHFR and 2756ag MetSyn genotypes, carriage of the 677ct MTHFR allele appears to affect formyl-H(4)PteGlu metabolism in non-NTD mothers.
|
10833329 |
2000 |
Neural Tube Defects
|
0.400 |
Biomarker
|
group |
BEFREE |
The gene for 5,10 methylenetetrahydrofolate reductase, an enzyme important in homocysteine metabolism, was studied in relation to NTDs.
|
8542260 |
1995 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
LHGDN |
MTHFR 677C-->T and 1298A-->C polymorphisms: evaluation of maternal genotypic risk and association with level of neural tube defect.
|
17085942 |
2007 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Analysis of data for the studied population does not prove the influence of mutations 677C-->T and 1298A-->C of MTHFR gene on NTDs.
|
12810988 |
2003 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our meta-analysis strongly suggested a significant association of the variant MTHFR C677T and a suggestive association of RFC-1 A80G with increased risk of NTDs.
|
23593147 |
2013 |
Neural Tube Defects
|
0.400 |
Biomarker
|
group |
BEFREE |
This study aims to evaluate the association between genetic defects in folate metabolism pathway genes, mainly: Folate hydrolase 1 (FOLH1), Dihydrofolate reductase (DHFR) and Methylenetetrahydrofolate reductase (MTHFR) and neural tube defects from eastern India.
|
30120883 |
2018 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Moreover, some authors demonstrated association of the C-->T mutation (C677T), converting an alanine to a valine residue in 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, with other congenital anomalies such as neural tube defects (NTDs).
|
11170082 |
2001 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The aim of this study was to evaluate whether the cytosine-to-thymine mutation at base 677 of the methylenetetrahydrofolate reductase gene (MTHFR C677T), which has been associated with neural tube defects and congenital oral cleft, is also associated with tetralogy of Fallot (TF), a congenital heart disease.
|
19894660 |
2009 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A common mutation, C677T, in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene leads to altered homocysteine metabolism, and has been associated with the occurrence of neural tube defects (NTD).
|
11337744 |
2001 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) is not a major risk factor for neural tube defect in American Caucasians. The NTD Collaborative Group.
|
10732818 |
1997 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Folate deficiency and the presence of the 677C > T (CT) polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene have been implicated in the causation of malformations in the fetus (particularly cleft lip and palate and neural tube defects).
|
17951123 |
2008 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Recently, an association between the homozygous C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene in infants with congenital neural tube defects or congenital oral clefts has been shown.
|
11470464 |
2001 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Levels of folate, vitamin B12, total homocysteine (t-Hcy) and the 677C>T and 1298A>C polymorphisms of the MTHFR gene were analyzed in 41 NTD child-mother pairs and 44 normal child-mother control pairs.
|
15259035 |
2004 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Conversely, our data provide no evidence for an association between NTD phenotype and combined MTHFR C677T/RFC-1 A80G genotypes.
|
12673279 |
2003 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The authors studied association of polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, which encodes enzymes of the folate pathway (implicated in causation of neural tube defects [NTDs]), in patients with AAD.
|
18074687 |
2007 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We designed molecular beacons to detect a point mutation in the methylenetetrahydrofolate reductase (MTHFR) gene, a mutation that has been related to an increased risk for cardiovascular disease and neural tube defects.
|
9510851 |
1998 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A variant form of methylenetetrahydrofolate reductase (MTHFR) (677C-->T) is a known risk factor for NTDs, but the prevalence of the risk genotype explains only a small portion of the protective effect of folic acid.
|
12384833 |
2002 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
LHGDN |
In conclusion, homozygosity for the C677T mutation in the MTHFR gene does not constitute a genetic risk factor for coronary artery diseases and neural tube defects in the Indonesian Javanese population.
|
12594357 |
2002 |