|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
CTD_human |
The authors performed a meta-analysis of studies examining the association between polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, including MTHFR C677T and A1298C, and common psychiatric disorders, including unipolar depression, anxiety disorders, bipolar disorder, and schizophrenia.
|
17074966 |
2007 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
To investigate the role of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene in schizophrenia in a gender-specific manner, we analyzed the genotypes of MTHFR677 and MTHFR1298 of 297 schizophrenic patients and 341 healthy controls, using a polymerase chain reaction restriction fragment length polymorphism method.
|
16084002 |
2005 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: evidence for a common genetic vulnerability?
|
21185933 |
2011 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To gain insight into the neural and molecular mechanisms of error processing, we used functional MRI to examine effects of a genetic variant in methylenetetrahydrofolate reductase (MTHFR 677C>T, rs1801133) that increases risk for schizophrenia and that has been specifically associated with increased perseverative errors among patients.
|
21980405 |
2011 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Elevated homocysteine levels and the MTHFR 677TT genotype are associated with an increased risk for schizophrenia.
|
15806605 |
2005 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion the results of the present meta-analysis suggested that the MTHFR C677T polymorphism is a risk factor for schizophrenia.
|
27025471 |
2016 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The present Scandinavian results do not verify previous associations between the putative functional MTHFR gene polymorphisms and schizophrenia or bipolar disorder.
|
18165967 |
2008 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that deficient MTHFR enzyme activity in pregnant women, related to the A1298C variant, is associated with a higher risk of having offspring affected with schizophrenia.
|
20044984 |
2010 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Gene-wide association study between the methylenetetrahydrofolate reductase gene (MTHFR) and schizophrenia in the Japanese population, with an updated meta-analysis on currently available data.
|
20692813 |
2010 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
No association between polymorphisms of methylenetetrahydrofolate reductase gene and schizophrenia in both Chinese and Scottish populations.
|
15289817 |
2004 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this study, we aim to verify the correlation between MTHFR polymorphisms and clinical features of schizophrenia, while exploring the differential genomic methylation and disease related genes as the potential targets for schizophrenia.
|
31476590 |
2019 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The aim was to detect a serum level of Hcy, examine the associations between the level of Hcy, methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and clinical properties for patients with schizophrenia, mood disorders and in a control group.
|
23586533 |
2014 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results indicated a strong association between MTHFR A1298C and schizophrenia.
|
22813657 |
2012 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
These data provide evidence supporting an association between MTHFR and risk of metabolic syndrome in patients with schizophrenia.
|
20547447 |
2010 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Two common, functional polymorphisms, catechol-O-methyltransferase (COMT) Val108/158Met and methylenetetrahydrofolate reductase (MTHFR) C677T, have separately been associated with executive function performance in schizophrenia.
|
18186041 |
2008 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Folate supplementation in schizophrenia: a possible role for MTHFR genotype.
|
21334854 |
2011 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results do not support a role for the C677T MTHFR variant in schizophrenia.
|
16969279 |
2006 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The three major MTHFR genotypes (G1793A, C677T, and A1298C) were examined in all subjects and the association between MTHFR polymorphism and clinical features of schizophrenia was analyzed.
|
31302825 |
2019 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This finding indicates possible association of BD and schizophrenia with the 1p36.3 MTHFR locus.
|
16545905 |
2006 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, neither winter birth nor MTHFR genotype were significantly associated with increased schizophrenia risk.
|
21093223 |
2011 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The MTHFR T677 allele and T677T and T677T/A1298A genotypes are genetic risk factors for schizophrenia.
|
14499487 |
2003 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
CTD_human |
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
|
18583979 |
2008 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
COMT and MTHFR polymorphisms interaction on cognition in schizophrenia: an exploratory study.
|
23353103 |
2013 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
CTD_human |
We measured the serum level of homocysteine/folate and methylenetetrahydrofolate reductase C677T/A1298C gene polymorphism in 235 patients with schizophrenia.
|
16641680 |
2006 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A second polymorphism, methylenetetrahydrofolate reductase (MTHFR) 677C --> T (rs1801133), has been associated with overall schizophrenia risk and executive function impairment in patients, and may influence dopamine signaling through mechanisms upstream of COMT effects.
|
18988738 |
2008 |