Schizophrenia
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest associations of the MTHFR gene variant with schizophrenia and depression in the Japanese.
|
9342205 |
1997 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Homozygous thermolabile methylenetetrahydrofolate reductase in schizophrenia-like psychosis.
|
9451725 |
1997 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that homozygosity for the T677 allele of the MTHFR gene is unlikely to play a major role in the pathogenesis of schizophrenia or affective disorders in our sample.
|
9774778 |
1998 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Plasma homocysteine and the methylenetetrahydrofolate reductase C677T gene variant: lack of association with schizophrenia.
|
10424670 |
1999 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results strongly suggest that the MTHFR gene is involved in the pathogenesis of schizophrenia characterized by a rapid and sustained therapeutic response to typical neuroleptics and/or a good long-term prognosis/favorable therapeutic outcome.
|
10889537 |
2000 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The MTHFR T677 allele and T677T and T677T/A1298A genotypes are genetic risk factors for schizophrenia.
|
14499487 |
2003 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Elevated Hcy levels and, in line with this finding, homozygosity for the 677C-->T mutation in the MTHFR gene were not associated with an increased risk for schizophrenia.
|
14572619 |
2003 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
No association between polymorphisms of methylenetetrahydrofolate reductase gene and schizophrenia in both Chinese and Scottish populations.
|
15289817 |
2004 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic analysis of the thermolabile methylenetetrahydrofolate reductase variant in schizophrenia and mood disorders.
|
15564899 |
2004 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Genetic analysis of the thermolabile methylenetetrahydrofolate reductase variant in schizophrenia and mood disorders.
|
15564899 |
2004 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We carried out a meta-analysis of MTHFR C677T genotype and schizophrenia risk, and found that TT homozygotes had a significantly increased risk, OR 1.48 (1.18-1.86).
|
15729744 |
2005 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Elevated homocysteine levels and the MTHFR 677TT genotype are associated with an increased risk for schizophrenia.
|
15806605 |
2005 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, these results do not confirm an independent relationship of tHcy and MTHFR genotype with risk of schizophrenia.
|
16076517 |
2005 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
To investigate the role of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene in schizophrenia in a gender-specific manner, we analyzed the genotypes of MTHFR677 and MTHFR1298 of 297 schizophrenic patients and 341 healthy controls, using a polymerase chain reaction restriction fragment length polymorphism method.
|
16084002 |
2005 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To investigate the role of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene in schizophrenia in a gender-specific manner, we analyzed the genotypes of MTHFR677 and MTHFR1298 of 297 schizophrenic patients and 341 healthy controls, using a polymerase chain reaction restriction fragment length polymorphism method.
|
16084002 |
2005 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
The elevated risk of schizophrenia associated with the homozygous genotype of the MTHFR 677C>T polymorphism provides support for causality between a disturbed homocysteine metabolism and risk of schizophrenia.
|
16172608 |
2006 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The elevated risk of schizophrenia associated with the homozygous genotype of the MTHFR 677C>T polymorphism provides support for causality between a disturbed homocysteine metabolism and risk of schizophrenia.
|
16172608 |
2006 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This finding indicates possible association of BD and schizophrenia with the 1p36.3 MTHFR locus.
|
16545905 |
2006 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
This finding indicates possible association of BD and schizophrenia with the 1p36.3 MTHFR locus.
|
16545905 |
2006 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
CTD_human |
We measured the serum level of homocysteine/folate and methylenetetrahydrofolate reductase C677T/A1298C gene polymorphism in 235 patients with schizophrenia.
|
16641680 |
2006 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We measured the serum level of homocysteine/folate and methylenetetrahydrofolate reductase C677T/A1298C gene polymorphism in 235 patients with schizophrenia.
|
16641680 |
2006 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results do not support a role for the C677T MTHFR variant in schizophrenia.
|
16969279 |
2006 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
CTD_human |
The authors performed a meta-analysis of studies examining the association between polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, including MTHFR C677T and A1298C, and common psychiatric disorders, including unipolar depression, anxiety disorders, bipolar disorder, and schizophrenia.
|
17074966 |
2007 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The authors performed a meta-analysis of studies examining the association between polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, including MTHFR C677T and A1298C, and common psychiatric disorders, including unipolar depression, anxiety disorders, bipolar disorder, and schizophrenia.
|
17074966 |
2007 |