Bladder Neoplasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Results from the current update analysis suggested that the C677T and A1298C polymorphisms in the MTHFR gene were associated with BC risk and disease progression.
|
23578207 |
2013 |
Bladder Neoplasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A comprehensive databases of Pubmed, Embase, Web of Science, and the Chinese Biomedical Database (CBM) were searched for case-control studies investigating the association between MTHFR Ala222Val polymorphism and bladder cancer susceptibility.
|
23773402 |
2013 |
Bladder Neoplasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis suggests that the MTHFR Ala222Val polymorphism not contributes to the development of bladder cancer.
|
23649653 |
2013 |
Bladder Neoplasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Bladder cancer cases were also 60% less likely to be homozygotes for the A allele in rs1476413 in MTHFR compared to controls (OR = 0.40; 95% CI = 0.18-0.88).
|
22747749 |
2012 |
Bladder Neoplasm
|
0.400 |
Biomarker
|
disease |
CTD_human |
Bladder cancer cases were also 60% less likely to be homozygotes for the A allele in rs1476413 in MTHFR compared to controls (OR = 0.40; 95% CI = 0.18-0.88).
|
22747749 |
2012 |
Bladder Neoplasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Consequently, the MTHFR gene C677T polymorphism augments the risk of bladder cancer in Turkey.
|
22126575 |
2011 |
Bladder Neoplasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results from the current update analysis suggest that C677T and A1298C polymorphisms in the MTHFR gene are associated with bladder cancer risk and prognosis.
|
22296361 |
2011 |
Bladder Neoplasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We also found that the MTHFR 677CT+1298AA genotypes were associated with an approximately 70% reduction in risk of bladder cancer (OR = 0.31; 95% CI = 0.15-0.68) compared to the combined referent genotype.
|
21046286 |
2011 |
Bladder Neoplasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It is concluded that the MTHFR 677TT genotype and the TTAA haplotype may increase the risk of bladder cancer.
|
20146887 |
2010 |
Bladder Neoplasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The MTHFR polymorphisms and their haplotypes appear to jointly contribute to risk of bladder cancer.
|
18815869 |
2009 |
Bladder Neoplasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, patients heterozygous for MTHFR A1298C or MTR A2756 G genotypes have 1.62- and 2.13-fold higher risk, respectively, of developing bladder cancer.
|
19837268 |
2009 |
Bladder Neoplasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Combined effect of NAT2, MTR and MTHFR genotypes and tobacco on bladder cancer susceptibility in Tunisian population.
|
19588544 |
2009 |
Bladder Neoplasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Assuming a very low prior probability of 0.000001, similar to a probability assumed for a randomly selected single-nucleotide polymorphism in a genome-wide association study, and statistical power to detect an OR of 1.5, 4 associations were considered noteworthy as denoted by an FPRP value <0.2: GSTM1 null and bladder cancer (OR, 1.5; 95% CI, 1.3-1.6; P = 1.9 x 10(-14)), NAT2 slow acetylator and bladder cancer (OR, 1.46; 95% CI, 1.26-1.68; P = 2.5 x 10(-7)), MTHFR C677T and gastric cancer (OR, 1.52; 95% CI, 1.31-1.77; P = 4.9 x 10(-8)), and GSTM1 null and acute leukemia (OR, 1.20; 95% CI, 1.14-1.25; P = 8.6 x 10(-15)).
|
18505952 |
2008 |
Bladder Neoplasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
While the isolated polymorphism C677T did not appear to influence bladder cancer susceptibility, results suggest that it might act with an additive contribution determined by variation at MTHFR A1298C.
|
17574963 |
2007 |
Bladder Neoplasm
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
While the isolated polymorphism C677T did not appear to influence bladder cancer susceptibility, results suggest that it might act with an additive contribution determined by variation at MTHFR A1298C.
|
17574963 |
2007 |
Bladder Neoplasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Because these dietary factors are involved in the one-carbon metabolism pathway, we evaluated associations between bladder cancer risk and 33 single nucleotide polymorphisms (SNPs) in 8 genes (CBS, CTH, MTHFR, MTR, MTRR, SHMT1, SLC19A1 and TYMS) and interactions with dietary variables involved in this pathway.
|
17311259 |
2007 |
Bladder Neoplasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To clarify the role of MTHFR polymorphisms on bladder cancer risk, we genotyped MTHFR 677C > T and MTHFR 1298A > C in a population-based study of bladder cancer of 352 patients and 551 controls from New Hampshire, USA.
|
16217917 |
2005 |
Bladder Neoplasm
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Polymorphisms of folate metabolic genes and susceptibility to bladder cancer: a case-control study.
|
15117811 |
2004 |