|
Lymphoma, Non-Hodgkin
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the methylene tetrahydrofolate reductase (MTHFR) gene have been reported as risk factors for non-Hodgkin lymphoma (NHL) in some populations.
|
28430351 |
2018 |
|
Lymphoma, Non-Hodgkin
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two common polymorphisms, the c. 677C > T and c. 1298A > C, of the methylene-tetrahydrofolate reductase (MTHFR) gene, an enzyme essential in DNA synthesis and methylation, have been associated with susceptibility to NHL.
|
28779180 |
2017 |
|
Lymphoma, Non-Hodgkin
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We searched available publications assessing the polymorphisms of MTHFR and NHL susceptibility from MEDLINE, EMBASE and CBM.
|
25146845 |
2014 |
|
Lymphoma, Non-Hodgkin
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the Indian ethnic subgroup however, single locus analysis of MTHFR A1298C appears to confer risk to NHL (Odds ratio (OR) 1.91, 95% confidence interval (95% CI) 1.22-3.00, P=0.006).
|
24646728 |
2014 |
|
Lymphoma, Non-Hodgkin
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to investigate the potential influence of the C677T and A1298C genetic variants of the methylenetetrahydrofolate reductase (MTHFR) gene on the clinical toxicity and efficacy of MTX in pediatric patients with NHL (n = 95) treated with therapeutic protocols Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) LNH-97 and EURO LB-02.
|
23488607 |
2013 |
|
Lymphoma, Non-Hodgkin
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the genetic polymorphisms in 5, 10-methylenetetrahydrofolate reductase (MTHFR 677C/T and 1298A/C) and to evaluate its associations with the risk of Non Hodgkin lymphoma.
|
23174714 |
2013 |
|
Lymphoma, Non-Hodgkin
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the role of single nucleotide polymorphisms (SNPs) in the folate-metabolizing genes MTHFR, MTR, MTRR, MTHFD, CBS and SHMT in regulating genetic susceptibility to Non-Hodgkin's lymphoma (NHL).
|
21055808 |
2011 |
|
Lymphoma, Non-Hodgkin
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and therapy-related toxicity in children treated for acute lymphoblastic leukemia and non-Hodgkin lymphoma.
|
19391036 |
2009 |
|
Lymphoma, Non-Hodgkin
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This is the first reported case of intracardiac thrombosis with MTHFR A1298C and factor XIII V34L mutations together with granulomatous reaction in non-Hodgkin lymphoma.
|
18432505 |
2008 |
|
Lymphoma, Non-Hodgkin
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that MTHFR, MTRR and TYMS polymorphisms may play a significant role in the risk for NHL.
|
18042267 |
2008 |
|
Lymphoma, Non-Hodgkin
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A meta-analysis of 11 studies conducted in Caucasian populations of European origin (4,121 cases and 5,358 controls) supported an association between the MTHFR Ex5+79 T allele and increased NHL risk (additive model, P = 0.01).
|
17891500 |
2007 |
|
Lymphoma, Non-Hodgkin
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that MTHFR gene variants play a critical role in NHL outcome, possibly by interfering with the action of methotrexate with significant effects on toxicity and survival.
|
17488658 |
2007 |
|
Lymphoma, Non-Hodgkin
|
0.400 |
Biomarker
|
disease |
CTD_human |
Our data suggest that MTHFR gene variants play a critical role in NHL outcome, possibly by interfering with the action of methotrexate with significant effects on toxicity and survival.
|
17488658 |
2007 |
|
Lymphoma, Non-Hodgkin
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we conclude that the MTHFR 677 C-->T polymorphism does not appear to influence outcome or therapy-associated toxicity in pediatric patients with NHL treated on BFM protocols.
|
16463153 |
2006 |
|
Lymphoma, Non-Hodgkin
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We observed no association between NHL and haplotypes for MTHFR or TYMS.
|
16365025 |
2005 |
|
Lymphoma, Non-Hodgkin
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The associations of DLCL and FL with TYMS 1494del6 and MTHFR 677TT genotypes, respectively, suggest that folate metabolism may play an important role in the pathogenesis of specific subtypes of NHL.
|
15198953 |
2004 |
|
Lymphoma, Non-Hodgkin
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In a case-control study, we evaluated whether four common polymorphisms in methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MS A2756G), and methionine synthase reductase (MTRR A66G) genes may have a role in altering susceptibility to adult acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphoma (NHL).
|
15159311 |
2004 |
|
Lymphoma, Non-Hodgkin
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We analysed genetic polymorphisms for methionine synthase (MS) A2756G, methylenetetrahydrofolate reductase (MTHFR) C677T and MTHFR A1298C in Caucasians with non-Hodgkin's lymphoma (NHL; n = 151), multiple myeloma (MM; n = 90) and 299 control subjects.
|
12648076 |
2003 |