MTHFR, methylenetetrahydrofolate reductase, 4524

N. diseases: 816; N. variants: 57
Disease: Disease of capillaries ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0155765
Disease: Disease of capillaries
Disease of capillaries 		0.020 AlteredExpression group BEFREE The role of hyperhomocysteinemia in microangiopathy in diabetes mellitus has been debated and is mainly seen with reduced activity of the MTHFR gene. 11531629 2001
CUI: C0155765
Disease: Disease of capillaries
Disease of capillaries 		0.020 GeneticVariation group BEFREE In the present study, we recruited 173 of Japanese type II diabetic patients with proliferative diabetic retinopathy who would be exposed to long-term hyperglycemia, and examined the contribution of the MTHFR gene polymorphism to the development of diabetic nephropathy as microangiopathy. 10765003 2000